Rochester Medicine 2022 Volume 1

aging reIMAGINED a new view of old age

On the cover Martha Hope is a driving force behind the University of Rochester Aging Institute’s community engagement. “It’s a partnership that allows us to connect with older people to promote education, health, and safety,” says Institute Director Annie MedinaWalpole, MD. “And, when I think about aging with vitality, Martha is the first person who comes to mind.”

POINT OF VIEW

Following in his footsteps: Colleen Schneider (MD ‘22) receives her hood from her 93-year-old grandfather, David Kluge (MD ’54), at the MD commencement ceremony in May.

CEO, University of Rochester Medical Center Dean, School of Medicine and Dentistry Senior Vice President for Health Sciences

All of us age at the same rate, but the impacts of aging affect each of us differently. Harnessing the collective curiosity and expertise of our faculty, URMC is working to discover how people can age with greater vitality than ever before.

That’s the guiding principle behind the University of Rochester Aging Institute (URAI). It builds on the legacy of T. Franklin Williams—a pioneering giant in the field of geriatrics, who served on our faculty across four decades in the late 20th century—to unite and bolster initiatives across the University. This collaborative effort combines scientists, clinicians, and learners to better understand how aging impacts health and what we can do to influence that.

Great strides in medicine have added years to our life expectancy, while simultaneously raising questions about what those added years will be like. Can people stay so active and productive that 70 becomes the new 40? How do we help older people and their families address the chronic diseases that become increasingly prevalent as years advance? Under the enthusiastic leadership of Dr. Annie Medina-Walpole, URAI is ideally poised to answer these questions.

Groundbreaking work by URMC researchers is uncovering the secrets of longevity, and harnessing the potential of RNA biology to prevent and treat diseases associated with aging. Innovative programs like the Geriatric Fracture Center have become international models in age-friendly clinical care. Continuous grant funding helps us train a workforce prepared to meet the distinct needs of older adults. Active engagement with the community assures that work within the Institute is relevant and meaningful to the population we serve.

I hope you enjoy this issue of Rochester Medicine and agree that the University of Rochester Aging Institute holds great promise for our University, and for all of us who aspire to long and fulfilling lives.

Thank you for your continued support and partnership.

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“It’s not how old you are, but how you are old.” -Jules Renard

$10M NIH Grant to Support URMC Research on Rheumatoid, Psoriatic Arthritis

Two URMC experts are leading research teams as part of a collaborative effort among the National Institutes of Health (NIH), U.S. Food and Drug Administration, pharmaceutical companies, and nonprofit organizations to study the cellular and molecular interactions that lead to inflammation and autoimmune diseases. Jennifer Anolik (PhD ’94, MD ’96, Res ’99, Flw ’01) professor and interim chief of Allergy, Immunology & Rheumatology, will serve as the principal lead for the rheumatoid arthritis (RA) team, and Christopher Ritchlin, MD (MPH ’08), professor of Allergy, Immunology & Rheumatology, will lead the psoriasis/psoriatic arthritis team.

The program adds URMC to the NIH Accelerating Medicines Partnership®: Autoimmune and Immune-Mediated Diseases (AMP AIM), a prestigious network of academic and clinical researchers. It’s supported by a $58.5 million grant that funds research across all institutions in the network for five years and is divided into four disease teams: rheumatoid arthritis (RA), lupus, psoriasis/psoriatic arthritis, and Sjogren’s disease, with multiple technical cores.

Anolik served as the RA lead and co-chair of the network on an earlier grant—the AMP RA/Lupus program—and is excited to expand her work. In addition to heading up the RA team, she is co-principal investigator on a technology grant with Harvard, for which she will lead the lab work on Sjogren’s at URMC, and is co-investigator with New York University on the lupus disease team.

It is estimated that these grants will bring more than $10 million to URMC over the course of funding.

The new grant will enable the implementation of high-dimensional technology that has been developed in the last decade and apply it to patient-focused research. The prior AMP grant allowed researchers to isolate single cells in target tissue for the first time for research in a “disease deconstruction” approach, and this next stage of the project will incorporate “disease reconstruction”—looking spatially within tissue to determine what cells are next to each other, how they communicate, and how environmental influences affect the cells and/or the disease.

Collaborations among URMC Cores have played a pivotal role in this research because

of their expertise and technological developments. Anolik worked closely with John Ashton (’08, PhD ’11, MBA ’17), director of the UR Genomics Research Center, to develop the single-cell approaches during the last grant. Spatial transcriptomics, a process that maps gene activity in a tissue sample, is being further spearheaded by Edward Schwarz, PhD, director of the Center for Musculoskeletal Research (CMSR), and Alayna Loiselle (PhD ’09), associate professor of Orthopaedics. CMSR has provided critical tissue processing for the AMP and will be an ongoing collaborator as spatial transcriptomics approaches are expected to be a key modality. Brendan Boyce, MBChB, professor of Pathology & Laboratory Medicine, will continue as a key collaborator for tissue histology.

“Relationships will help solve problems in all diseases,” said Anolik. “The collaboration of multiple departments within URMC is key, but combining research with the other institutions in the AMP AIM network is critical as well, because of the value of input from different places across the country, even the world, where expertise, environmental factors, and patient populations may be different.”

Advancing Treatment

URMC Part of Collaboration Awarded $10M for Pediatric Concussion Research

Researchers at URMC are part of a collaborative project, led by the University of California, Los Angeles, that will study concussions in children and teens. The project, which was awarded $10 million from the National Institute of Neurological Disorders and Stroke, will test ways to predict which kids will develop persistent symptoms after a concussion, so researchers can study how to help them recover faster.

The grant to the Four Corners Youth Consortium, a group of academic medical centers studying pediatric concussions, will support Concussion Assessment, Research and Education for Kids— or CARE4Kids—a multisite study that will enroll more than 1,300 children and teens nationwide, including an estimated 240 in the Rochester area.

Every year, more than 3 million people in the U.S. are diagnosed with concussions. Symptoms continue to plague 30 percent of patients three months after injury, and adolescents face an even higher risk of delayed recovery. Chronic migraine headaches, learning and memory problems, exercise intolerance, sleep disturbances, anxiety, and depressed mood are common.

The pre-teen and teen years are critical for psychosocial and brain development, and researchers fear what long-lasting concussion symptoms could mean for the developing brain.

“Prolonged concussion recovery can have an enormous impact on the lives of teens and pre-teens, often setting the stage for academic difficulties, persisting mood disorders, and chronic pain,” said Jeffrey Bazarian (MD ’87, Res ’90, MPH ’02), professor of Emergency Medicine at URMC, who will lead the Rochester study site. “Early evaluation and treatment for kids at high risk for prolonged recovery is our best hope for preventing an acute injury from becoming chronic.”

In addition to URMC, the study is also currently recruiting participants at UCLA Mattel Children’s Hospital, Children’s National, Seattle Children’s, the University of Washington, the University of Texas Southwestern Medical Center, and Wake Forest School of Medicine. Indiana University, the National Institute of Nursing Research, the University of Arkansas, the University of Southern California, and the University of Utah are also involved.

The URMC team also includes Jonathan Mink, MD, PhD, the Frederick A. Horner, MD, Distinguished Professor in Pediatric Neurology, and Spencer Rosero, MD (Res ’96, Flw ’00), professor and interim chief of Cardiology.

The study, which focuses on children between the ages of 11 and 18, will unfold in two phases. The first part will evaluate children with concussions to identify a set of biomarkers—including those related to changes in blood pressure, heart rate, and pupil reactivity—that could predict which kids will develop persistent symptoms after a concussion. The next will seek to confirm that these biomarkers accurately predict prolonged symptoms in a second group of children diagnosed with concussions.

Ultimately, the team hopes to develop an algorithm to help health care providers diagnose and treat concussions and enable the development of therapies that could help kids recover from concussions more quickly.

“Discovering objective biomarkers for persistent post-concussion symptoms will permit earlier intervention and future use of specific treatments for these patients,” said national project leader Christopher Giza, MD, director of the UCLA Steve Tisch BrainSPORT Program and professor of Pediatrics and Neurosurgery at UCLA’s David Geffen School of Medicine and Mattel Children’s Hospital. “Our big goal is to alleviate suffering and promote maximal recovery.”

Infectious Diseases

‘Immune Distraction’ from Previous Colds Leads to Worse COVID Infections

A URMC study shows that prior infection and immunity to one of the common cold coronaviruses may have put people at risk of more severe COVID illness and death.

Published in the Journal of Infectious Diseases, the study examined immunity to various coronaviruses, including the COVID-causing SARS-CoV-2 virus, in blood samples taken from 155 COVID patients in the early months of the pandemic. Of those patients, 112 were hospitalized and provided sequential samples over the course of their hospitalization.

These hospitalized patients experienced a large, rapid increase in antibodies that targeted SARS-CoV-2 and several other coronaviruses. While big boosts in antibodies is usually a good thing, in this case it wasn’t.

The study showed that these antibodies were targeting parts of the spike protein, which sits on the surface of coronaviruses and helps them infect cells that were similar to common cold coronaviruses the immune system remembered from previous infections.

Unfortunately, targeting those areas meant the antibodies could not neutralize the new SARS-CoV-2 virus. When levels of these antibodies rose faster than levels of SARS-CoV-2 neutralizing antibodies, patients had worse disease and a higher chance of death.

“In people who were sicker—those who were in the ICU or died in the hospital, the immune system was responding robustly in a way that was less protective,” said lead study author Martin Zand, MD, PhD, senior associate dean of Clinical Research at URMC. “It took those patients longer for the immune system to make protective antibodies… unfortunately, too late for some.”

This study adds to a growing pool of evidence that immune imprinting is at play in COVID immune responses. Zand, who is also a co-director of the University of Rochester Clinical and Translational Science Institute, likens this phenomenon to “immune distraction”: immunity to one threat (seasonal coronaviruses) hijacks the immune response to a new, but similar, threat (SARS-CoV-2). Immune imprinting has been linked to poor immune responses to other viruses, like flu, and can have implications for vaccine strategies.

By some predictions, COVID is likely to be with us for a long time—with new, milder strains emerging and circulating on an annual or seasonal basis. If those predictions hold true, the study suggests that we will need to regularly develop new vaccines targeting the new strains of SARS-CoV-2. While none have come to market yet, pharmaceutical companies such as Pfizer and Moderna have been developing and testing new versions of their COVID vaccines as new variants of concern have emerged.

“We should expect that development of new vaccines is a good thing,” said Zand. “It doesn’t mean the original science was wrong. It means nature has changed. If we want an immune system that pays attention to the right stuff, we need to teach it new tricks with different vaccines.”

More Oversight Needed to Improve End-of-Life Care for Assisted Living Residents

Residents of assisted living facilities in states with less rigorous regulations are more likely to die without hospice or at-home end-of-life care, according to a study led by URMC’s Helena Temkin-Greener, PhD, professor of Public Health Sciences, that was published in the journal Health Affairs

Unlike nursing homes, which are highly regulated by federal and state governments, assisted living communities fall under greatly varying oversight for issues such as minimum staffing levels, depending upon where a person lives. While assisted living communities have become a more common residential care choice for older Americans who require assistance with daily care needs and other supportive services, regulation of these communities varies from state to state, and there has been little analysis of care outcomes.

The study looked at end-of-life care for 100,783 residents who died in 2018–2019 in 16,560 assisted living communities, and specifically at whether they died at home

and under hospice care or after transfer to a nursing home or hospital. Overall, 60 percent of Medicare fee-for-service beneficiaries residing in assisted living died at home, and more than 84 percent of them had hospice care. The probability of dying at home was significantly lower by dual Medicare-Medicaid status but not by race or ethnicity, suggesting dual-status residents may have worse access to high-quality end-of-life care.

Black residents were significantly less likely to be enrolled in hospice before death; several previous studies have shown that Black families are more likely to advocate for continued and aggressive medical treatment at the end of life—a legacy of mistrust in the health care system. Residents were also less likely to die at home or with home hospice in states with lower regulatory oversight of assisted living communities.

Study authors believe these findings should help inform efforts to ensure more equitable access to end-of-life care planning and services in assisted living communities

and suggest an important role for state-level regulation in their implementation.

This research was supported with funding from the Agency for Healthcare Research and Quality and the Patrick and Catherine Weldon Donaghue Medical Research Foundation.

Strong Expansion Project

Strong to Triple Size of ED, Add 100+ Private Inpatient Rooms

An extensive expansion project at Strong Memorial Hospital will add 200 examination/treatment and patient observation stations to the Emergency Department and Comprehensive Psychiatric Emergency Program, as well as a nine-story inpatient bed tower to include more than 100 private rooms. Scheduled for completion in 2027, the project will help to address chronic bed shortages and ED overcrowding issues, which existed prior to but were exacerbated by the COVID pandemic.

University of Rochester President Sarah Mangelsdorf described the expansion, which will add more than 650,000 square feet of new hospital space, as an investment in the community and the medical center. “Educationally, it is a powerful medical-center asset to have a large teaching hospital integrated physically with our three professional schools for clinicians and with the research labs where medical discoveries are made,” she said. “This project will represent a critical investment in modernizing our community’s and our region’s largest hospital for 21st century needs.”

Highlights of the project include:

■ Specially designed clinical spaces to serve patients with cardiovascular disease, including ICUs and dedicated inpatient rooms.

■ The most comprehensive modernization project since the current patient tower was completed in 1975, providing private rooms for all patients.

■ ED expansion from 46,000 to 175,000 square feet, including a Fast Track section enabling patients with lower-acuity concerns to be treated and released quickly.

■ A larger, covered entrance to serve patients as they arrive, with a more efficient triage and registration area and larger waiting room.

■ An 80,000-square-foot parking garage.

Environmental Science Study Links Fracking, Drinking Water Pollution, and Infant Health

Public water supplies are polluted by shale gas development, commonly known as fracking, and can impact infant health, according to a URMC study published in the Journal of Health Economics. The findings call for closer environmental regulation of the industry, since levels of chemicals found in drinking water often fall below regulatory thresholds.

“In this study, we provide evidence that public drinking water quality has been compromised by shale gas development,” said study co-author Elaine Hill, PhD, an associate professor with the University of Rochester Departments of Public Health Sciences, Economics, and Obstetrics & Gynecology. “Our findings indicate that drilling near an infant’s public water source yields poorer birth outcomes and more fracking-related contaminants in public drinking water.”

Hill’s previous research was the first to link shale gas development to drinking water quality and has examined the association between shale gas development and reproductive health, along with the subsequent impact on later educational attainment, higher risk of childhood asthma exacerbation, higher risk of heart attacks, and opioid deaths. Her research brings an important perspective to the policy discussion about fracking, which has often emphasized the immediate job creation and economic benefits without fully understanding the long-term environmental and health consequences for communities in which drilling occurs.

This new study is a complex examination of the geographic expansion of shale gas drilling in Pennsylvania from 2006 to 2015, during which more than 19,000 wells were established in the state. Hill and co-author Lala Ma, PhD, of the University of Kentucky, mapped the location of each new well in relation to groundwater sources that supply public drinking water. They linked this information to maternal residences served by those water systems, as indicated on birth records, and U.S. Geological Service groundwater contamination measures. This data set allowed the two to pinpoint infant health outcomes—specifically, preterm birth and low birth weight—before, during, and after drilling activity.

Other studies have shown elevated levels of chemicals associated with fracking in surface water; however, these levels often tend to be below federal guidelines, are not monitored closely, and even if detected, do not rise to levels that trigger remediation. Hill’s and Ma’s study indicates that fracking-related chemicals—including dangerous volatile organic compounds—are making their way into groundwater that feeds municipal water systems, and that the potential for contamination is greatest during the pre-production period when a new well is established. With only 29 out of more than 1,100 shale gas contaminants regulated in drinking water, the results suggest that the true contamination level is higher. The study specifically finds that every new well drilled within one kilometer of a public drinking water source was associated with an 11 to 13 percent increase in the incidence of preterm births and low birth weight in infants exposed during gestation.

“These findings indicate large social costs of water pollution generated by an emerging industry with little environmental regulation,” said Hill. “Our research reveals that fracking increases regulated contaminants found in drinking water, but not enough to trigger regulatory violations. This adds to a growing body of research that supports the re-evaluation of existing drinking water policies and possibly the regulation of the shale gas industry.”

Innovation Huntington’s Study Recognized for Potential to ‘Shape Medicine’

The journal Nature Medicine has identified a phase-3 study of pridopidine—a promising treatment for Huntington’s disease—as one of 11 clinical trials that will shape medicine in 2022. The URMC Clinical Trials Coordination Center (CTCC) is providing global operational support for the study, which is being conducted at more than 50 sites across the U.S., Canada, the U.K., and Europe.

The journal notes that the PROOF-HD clinical trial is one of several ongoing studies of pridopidine as a potential therapy for Huntington’s, ALS, and other neurodegenerative diseases. Pridopidine is an oral small-molecule compound that binds and activates the Sigma-1 receptor (S1R), which is present at high levels within the brain. By activating S1R, the drug helps boost production of brain-derived neurotrophic factor, a protein with neuroprotective properties. This protein is found at reduced levels in people with Huntington’s disease.

The PROOF-HD study is being conducted by Prilenia, the drug’s manufacturer, and HSG—a global network of more than 400 investigators, coordinators, scientists, and Huntington’s disease experts. CTCC has collaborated with HSG on a number of clinical trials, including the First-HD study, which led to the FDA’s 2017 approval of deuterated tetrabenezine for Huntington’s.

CTCC is providing scientific, technical, logistical, and operational logistical support for the PROOF-HD study, which is anticipated to run through April 2023.

Part of the Center for Health + Technology, CTCC is a unique academic-based research organization with decades of experience working with industry, foundations, and governmental researchers in bringing new therapies to market for neurological disorders. Since its inception in 1987, it has played a central role in bringing seven new drugs to market to treat Parkinson’s disease, Huntington’s disease, and periodic paralysis.

Elise Kayson (MSN ’84), RNC, ANP, director of CTCC Clinical and Strategic Initiatives and Huntington Study Group (HSG) co-chair, is project lead for the PROOF-HD study.

Mental Health Research

Major Grant Funds Research to Understand Key Features of OCD: Inflexibility and Avoidance

A team of scientists from across the country will use a $15.6 million award from the National Institute of Mental Health to investigate the brain networks central to obsessive compulsive disorder (OCD). The work will build on more than 15 years of research by lead investigator Suzanne N. Haber, PhD, and collaborators to further understand the underlying biology of the disease and guide the development of effective treatments.

“Obsessive compulsive disorder is among the most disabling psychiatric disorders,” said Haber, professor of Pharmacology and Physiology, Neuroscience, and Psychiatry.

“It affects 1 to 3 percent of the population worldwide, yet it hasn’t received the same level of attention as other mental health disorders. We’re excited to receive this funding and use translational methods to understand circuit dysfunction in the disease and to develop new treatment approaches that can improve the lives of patients.”

The five-year grant funds a Silvio O. Conte Center for Basic and Translational Mental Health Research at the University of Rochester. Haber has received previous Conte

Center grants that have propelled scientists’ understanding of the disease. Major findings include the discovery of a narrower, more defined network of brain regions, dubbed the “OCD network,” that underlie the disorder. The new grant will allow scientists to test the idea that behavioral inflexibility in OCD results from faulty connections between brain circuits in this network.

“The identification of the OCD network is the result of years of research by us and others that demonstrates a set of connected brain structures that are central to linking stimuli to decisions that we make about actions that lead to certain outcomes,” Haber said.

Individuals with OCD often compulsively avoid or take specific actions to avoid a potential bad outcome, despite a low likelihood of that outcome occurring. The action persists despite the awareness that it is not productive. “By studying this network and its role in different aspects of decision making and behavioral flexibility, we hope to better understand how dysfunction of neural connections can result in obsessions and compulsions,” she said.

The University of Rochester team will combine studies of anatomy with high-resolution diffusion and functional imaging to identify relevant connections in the OCD network. This data will help scientists probe abnormalities by using imaging tools in people with OCD. It will also help identify individual variation in critical network locations. Finally, these results will be used to explore new ways to modulate the network, such as through the use of deep brain stimulation and low-intensity focused ultrasound.

Haber notes that the OCD network, which regulates normal behaviors related to the flexibility of responses, is central not only to OCD, but a wide range of other mental health conditions, such as depression, post-traumatic stress disorder, and addiction. Findings from this work could influence the management of these illnesses as well.

The University of Rochester is one of six institutions participating in the research.

Documentary Sheds Light on the Parkinson’s ‘Pandemic’

A documentary produced by the University of Rochester Center for Heath + Technology (CHeT), The Long Road to Hope, tells the story of individuals with Parkinson’s and efforts to study, treat, and prevent the disease from a global perspective.

The film features 12 patients with Parkinson’s from the U.S., Canada, the U.K., and the Netherlands, along with medical commentary from URMC Neurologist Ray Dorsey, MD, and Bas Bloem, MD, PhD, of Radboud University Medical Center in the Netherlands.

Dorsey and Bloem discuss the pandemic scope of this largely preventable disease and how addressing it will require a global effort with the same level of focus and resources employed with success to address other public health challenges, such as polio, HIV, and breast cancer.

The film is an outgrowth of ParkinsonTV, a video series launched in 2017 by CHeT and Bloem’s team, which had already created a Dutch-language version of the series. The third season of the English series includes the full documentary plus episodes featuring patients in the film and is available and free to watch on the ParkinsonTV website (parkinsontv.org/three).

The Long Road to Hope was produced and directed by Norman Yung, Alistair Glidden, and Iyad Amer, along with CHeT, and supported by a grant from Roche.

Living Donation Opens New Doors for Colorectal Cancer Patients in Need of Liver Transplants

Nearly three years ago, Doug Vincent was given a year to live, having been diagnosed with stage four colorectal cancer that had spread to his liver and was too extensive to be removed. Today, he is alive and cancer-free, thanks to a living-donor liver transplant conducted through an innovative clinical trial at URMC.

for patients with colorectal liver metastases than any other center in North America. “With this, we’re opening opportunities for patients to live longer—and for some of them to be cured.”

The study, which was conducted across URMC, the University Health Network, and

means their liver tumors are the only things standing between them and a “cancer-free” label. It also increases the odds that these patients—and their new livers—will remain cancer-free, which is crucial when balancing the benefit to the patient with the risk to a living donor.

“I’ve seen so many cancer patients whose cancer was not spreading, but we couldn’t remove the tumors from their liver and we knew they would die,” said Hernandez-Alejandro, who is also an investigator at the Wilmot Cancer Institute. “We hoped living-donor liver transplant could give them another chance.”

Because it offered a last resort, the study attracted more than 90 patients from near and far. All patients and donors went through a rigorous virtual and in-person screening process to ensure they were good candidates for the procedure, and they were educated about the risks of the surgery and the possibility of cancer recurrence. Patients and donors underwent staggered surgeries to fully remove patients’ diseased livers and replace them with half of their donors’ livers.

Patients have been closely monitored via imaging and blood analysis for any signs of cancer recurrence and will continue to be followed for up to five years after their surgeries. At the time the study was published, two patients had follow-ups of two or more years, and both remained alive and well—cancer-free.

Vincent was one of 10 patients treated through a study published in the Journal of the American Medical Association Surgery, demonstrating the first successful living-donor liver transplants in North America for patients who have liver-confined colorectal cancer tumors that cannot otherwise be removed by surgery.

According to the study, a year and a half after their living-donor liver transplants, all 10 patients were alive, and 62 percent remained cancer-free.

“This [study] brings hope for patients who have a dismal chance of surviving a few more months,” said first author of the study, Roberto Hernandez-Alejandro, MD, chief of the Abdominal Transplant and Liver Surgery Division at URMC. The division has performed more living-donor liver transplants

Cleveland Clinic, focused on colorectal cancer in part because of its tendency to spread to the liver. Nearly half of all patients with colorectal cancer develop liver metastases within a few years of diagnosis, and 70 percent of liver tumors in these patients cannot be removed without removing the entire liver.

Unfortunately, deceased-donor liver transplant is not a viable option for most of these patients because their liver function is fairly normal—despite their tumors. That lands them toward the bottom of the national organ-transplant waiting list. In North America, one in six patients on this list dies each year while waiting for an organ.

Thanks to recent advances in cancer treatments, many of these patients are able to get their cancer under systemic control, which

“This study proves that transplant is an effective treatment to improve quality of life and survival for patients with colorectal cancer that metastasized to the liver,” said senior study author Gonzalo Sapisochin, MD, a transplant surgeon at the Ajmera Transplant Centre and the Sprott Department of Surgery at the University Health Network.

“As the first successful North American experience, it represents an important step toward moving this protocol from the research arena to standard of care,” adds Sapisochin, who is also a clinician investigator at the Toronto General Hospital Research Institute and an associate professor in the Department of Surgery at the University of Toronto.

Roberto Hernandez-Alejandro, MD

“This [study] brings hope for patients who have a dismal chance of surviving a few more months.”

aging reIMAGINED

MAGINED

a new view of old age

One day in 2012, a group of women and men ages 50 to 91 stood, awkward and shivering, on a pool deck at Monroe Community College in Rochester.

For some, it was the first time in years they had worn a swimsuit in mixed company. It was also the first day they would train for a triathlon.

For eight weeks, they ran, cycled, and swam their way into race fitness. Two months later, more than 50 athletes lined up for the running leg of the race, and a vanguard of local Hell’s Angels’ riders, most in their late sixties or so, started them off with a roar.

...WE OFTEN SELL OLDER PEOPLE SHORT IN TERMS OF WHAT THEY CAN DO...

Almost everybody finished the certified sprint course triathlon with a 750-meter swim, 12-kilometer bike ride, and five-kilometer run all on the same day.

“We were presenting them with a life option that they never would have thought possible, and within a week everybody was doing wonderful things. It was an enormous success,” says University of Rochester Medical Center Professor Emeritus William Hall, MD, who created the event with Carol Podgorski (MPH ’85, PhD ’90, MS ’05), professor of Psychiatry. At the time, Podgorski and Hall headed the Center for Lifetime Wellness, which supported the training. AARP provided funds to develop and host it, the first of its kind in New York state.

“What it did for me was solidify this idea that we often sell older people short in terms of what they can do,” Hall says. “That’s when things really got started. It was an amazing example of what is possible to do in Rochester.”

Off and Running

Training for the tri continued for several more summers. By the end of the program, the concept of conditioning and training for adults ages 50 and over had gained a solid footing.

It was the natural outgrowth of a University of Rochester tradition in geriatrics that began in the 1960s, long before a focus on healthy

aging caught on elsewhere. Fifty years before Hall’s triathletes jumped into the pool at MCC, T. Franklin Williams, MD, was making waves with geriatrics care and research in Rochester. One of the founders of modern geriatrics medicine and a giant in the field (he directed the National Institute for Aging for eight years), Williams placed Rochester at the forefront of geriatrics before it was even a specialty. (See sidebar on page 17.)

Williams mentored countless geriatricians across the country, including Hall and others who remained on home ground and built on his success. Today, geriatricians and scientists in the University of Rochester Aging Institute (URAI) are known around the world for groundbreaking research and older-adult care models.

The volume of bench research, patient care, and community support related to aging in Rochester is staggering. From fracture centers to DNA research to community music programs for older adults, URAI integrates all such strengths across campuses. Many of these are replicated around the world. And experts here are sharing and collaborating more easily.

“Promoting vitality in aging through discovery, collaboration, and innovation is what this Institute is all about!” says Annette (Annie) Medina-Walpole, MD, chief of the Division of Geriatrics & Aging, who directs the Institute with a contagious enthusiasm. “The UR Aging Institute is committed to promoting health, independence, and engagement, enabling all of us to live our best lives.”

Redefining Aging

Geriatricians have heard all the stereotypes of old age, usually starting with “it’s tough growing old,” followed by a list of ailments and an inevitable downward spiral of loss and limitations.

However, scientists and clinicians in the URAI say the picture doesn’t fit everyone’s experience of aging, nor did it ever: They are blowing those stereotypes out of the water, proving older adults can be capable of far more—cognitively, physically, socially—than previously believed. Vital and healthy advanced age is not only possible; for a growing number, like Hall’s triathletes, it’s what everyone should strive for.

Hall and Susan Friedman, MD, MPH, professor of Medicine in the Division of Geriatrics & Aging, have continued the quest to promote healthy aging. A 2015 article they published in the Journal of the American Geriatrics Society notes that “collaborative efforts between geriatrics, communities, and individuals will set the stage for developing a healthier society for all to age well and successfully.” Friedman has gone on to publish additional papers on healthy aging and to launch the Lifestyle Medicine program at Highland Hospital.

“People often think that aging is this inevitable decline. Forget about a fountain of youth. But it seems that the process of aging is really malleable and can be influenced,” says Dirk Bohmann, PhD, senior associate dean for Basic Research and the Donald M. Foster, MD, Professor in Biomedical Genetics, who has studied aging for more than 20 years.

The need to study aging and to shift societal attitudes has never been more urgent. More than 10,000 people in the U.S. turn 65 every day, and the number of older adults will more than double to 88 million by 2050, according to the AARP. That’s more than 20 percent of the population. Not surprisingly, funding for aging research—from the National Institute on Aging and a growing roster of other sources—is on a steady rise.

Far from a bleak outpost of last-chance medicine, aging research and geriatrics medicine turn out to be an exciting place.

T. Franklin Williams: Geriatrics Visionary

Into his late eighties, one of the founders of modern geriatric medicine rode his bike to work every day from his home on Park Avenue to Monroe Community Hospital (MCH).

Rochester’s reputation for aging expertise can be traced back to T. Franklin Williams, MD. Long before the specialty had a name, he trained a generation of geriatricians who went on to become leaders in the field.

Williams and his wife, Catharine Carter Catlett Williams, a social worker and early advocate for restraint-free nursing homes, came to Rochester in 1968 from the University of North Carolina. He was recruited as a professor of Medicine and to direct MCH, which remains a major center for geriatrics care and education in the Rochester community. Teaching was one of his greatest joys, former fellows recall, and he established one of the first geriatrics fellowship programs in the country. As his reputation grew, he was asked to lead the National Institute on Aging, which he did for eight years in the 1980s and ’90s under two administrations. When he was done, Williams returned to Rochester to continue his work for another 20 years.

“We were lucky to have Frank and his wife, Carter. They were really the beginning of it,” says geriatrician Robert McCann, MD, former chief of Medicine at Highland Hospital and CEO of Accountable Health Partners, URMC’s clinically integrated network of hospitals and physicians. “He was such a humble, wonderful man.”

The RoAR and OARHS of Research

Basic aging research began in earnest at the University many years ago. Bohmann and University professors of Biology and Medicine Vera Gorbunova, PhD, and Andrei Seluanov, PhD, formed RoAR, Rochester Aging Research Center, bringing together investigators in basic and translational research at the Medical Center and River Campus through seminars, an Aging Research Day, pilot grants to advance the work, and ways to collaborate.

Podgorski and Professor and Vice Chair of Psychiatry Yeates Conwell, MD, started OARHS, the Office of Aging Research and Health Services, to gather clinicians, researchers, and educators in clinical care and population health. As a complement to basic research, it was a first step in linking basic scientists, clinicians, caregivers, and policy experts around the University.

While the two efforts weren’t officially siloed, neither were they connected in any real, change-making way. Collaboration between lab scientists and geriatricians wasn’t natural at first, Bohmann recalls.

“RoAR did basic research on the fundamentals of aging, the science behind it, whereas OARHS and geriatrics work on the actual state of being old. These are two different cultures. Still, we figured it would be very useful to support communication between them,” he says.

They came together in the newly formed URAI in 2019, spurring a whole new level of excitement and potential for the study of aging and the care of older adults in our health system and community.

The Age-Friendly Health System

At every level of care and in every setting, age-friendly health systems follow four elements of high-quality care, the 4Ms:

■ What Matters to You—Know and align care with the older adult’s specific health outcome goals and preferences

■ Mentation—Prevent, identify, treat, and manage dementia, depression, and delirium

■ Mobility—Ensure the older person moves safely every day

■ Medication—If it’s necessary, make sure it doesn’t interfere with the other three Ms

An Age-Friendly Focus

From a clinical point of view, creating an institute that addresses an increasing need is important, says Mark Taubman, MD, URMC CEO and dean of the School of Medicine and Dentistry. The UR Aging Institute plays a huge part in the University’s strategic plan and mission: to improve the health of the region’s population and enhance UR’s reputation as a research-oriented university and medical center.

To that end, in May 2022, Strong Memorial and Highland hospitals received the highest level of certification as an Age-Friendly Health System (AFHS), an initiative of the Institute for Healthcare Improvement and the John A. Hartford Foundation with the American Hospital Association and the Catholic Health Association of the United States.

As the name suggests, AFHS certification is the best in evidence-based health care for older adults. It’s a focus on what matters to patients receiving care and on improving health outcomes for them—and a perfect fit with the URAI’s mission.

“Right now we have a region that’s not growing in population—it’s aging. More and more of the people we take care of are an aging population, and the diseases are age-related,” Taubman says. “We have an opportunity—because of who we are and what we already do with aging—to make a national mark. And we’re ripe to do it.”

We have an opportunity— because of who we are and what we already do with aging— to make a national mark. And we’re ripe to do it. -Mark Taubman

“I look at it as a ‘no wrong door’ approach. Any older adult who comes in, no matter what their need is, they’ll have consistent, evidence-based care that is focused on the unique needs of older adults,” says Thomas Caprio, MD (Res ’03, Flw ’05, MPH ’10, MS ‘15), principal investigator of the Geriatric Workforce Enhancement Program (GWEP) grant and director of the Finger Lakes Geriatric Education Center. The GWEP grant and the URAI fund Geriatric Faculty Scholars from the School of Nursing and Medicine/Dentistry to become geriatrics champions and further disseminate the AFHS within their own specialty, program or department.

Thomas Caprio, MD

Promoting Vitality in Aging

In the Institute’s three main areas—research, care, and community— University of Rochester experts are pushing against traditional boundaries of what aging looks like. They’re questioning long-held, limiting assumptions about the physical, mental, emotional, and social abilities of older adults. And they’re doing things quite differently in their clinical studies and scientific investigations.

vital DISCOVERY

Research ranges from basic science in the lab to data science and multidisciplinary aging studies. Scientific discoveries will be translated into creative approaches to increase longevity and health span as well as improve patient care and clinical outcomes.

(See page 22.)

vital CARE

The primary aim is to increase access to high-quality geriatrics care—driven by technology and data—in the region. URAI makes sure best practices and care models are shared across the system. A big focus is on workforce education, including training providers of all disciplines and disseminating the principles of the AFHS.

(See page 30.)

vital LIVING

This pillar focuses on older adults in the Rochester community. It creates a loop of learning that goes both ways between the University and community nonprofits and individuals. URMC specialists and aging organizations offer evidence-based evaluations and lifestyle interventions that promote vitality in aging. And older adults become advocates, teachers, and researchers themselves, enlivening the university community with the spirit of aging. (See page 34.)

Aging research is a wide-open field with a lot of exciting perspectives. But with abundant opportunities come challenges. For the Institute, this means being selective.

“We started by building on our existing strengths—and there are many—and now we are moving forward by creating new, unprecedented partnerships and collaboration across our institution that align with our mission and vision,” Medina-Walpole says.

“We’re not going to do this all at once,” adds Conwell, a member of the URAI executive committee. “Why did we take on a mission for the Institute that is as broad as this is, to include research and education and clinical care and population health? It has to do with the notion of the biopsychosocial model.”

The BPS model, the foundation of medical training and care at the University of Rochester, insists on treating not only the physical but the emotional, mental, and social aspects of health. It was conceived by URMC doctors George Engel and John Romano in the 1970s and is now in wide use around the world.

“It is inherently in the air we breathe here, and we want to disseminate that and make that an important part of how we work,” Conwell says.

Rochester is the perfect living laboratory to re-envision older age, says Hall, noting that he and colleagues who came up under Williams had support not only from the University but from the community.

“There are so many resources to help people age gracefully in Rochester,” he says. “That is probably not as well known here as it is nationally. Somehow this community saw the tea leaves and really tried to develop collaborative programs, so Rochester is well-recognized throughout the country for that form of leadership.

“If you’re going to have to age anyway, you might as well do it here in Rochester.”

The Possibilities of ‘Yes’

Annie Medina-Walpole, MD, has built a career around one word: yes.

“I said ‘yes’ more than ‘no’. I think that opens so many doors,” says the chief of the Division of Geriatrics & Aging, the Paul H. Fine Professor of Medicine, and director of the UR Aging Institute.

Her latest “yes” was an enthusiastic one to URMC CEO and SMD Dean Mark Taubman, MD, who in 2016 charged her with building the Institute. At the time, she was the University’s representative to the Hedwig van Ameringen Executive Leadership in Academic Medicine (ELAM) program, a prestigious, yearlong, national fellowship for women in medicine. She started building a plan for the Institute as her fellowship project, bringing together people from every corner of the University to create an infrastructure and priorities in each area.

Medina-Walpole is a familiar name in the world of American geriatrics. She joined the American Geriatrics Society as a chief resident, and by midcareer she was on the board, serving as president in 2020-2021. Right now, she’s co-leading an examination of diversity, equity, and inclusion for the 6,000-member society, urging a rethink on ageism and racism in health care, particularly for older people of color—an issue that came to light during the pandemic.

“It’s not about just hosting a training session or webinar, a one-and-done. We’re embedding this work into the fabric of our society,” she says. “We’re creating a multi-year, multi-pronged approach to address the intersection of structural racism and ageism. Our ultimate goal is health care systems that are free of discrimination and bias.”

Medina-Walpole has held just about every leadership post in geriatrics education at URMC since joining the faculty in 1998. She sees her role in the Institute as that of a convener, a connector, and a mentor. Outside the University, she is helping to stitch the Institute into the wider community, where, like Medina-Walpole herself, older adults are building networks of their own to improve the lives of their peers.

“We are not just focused on how we can help older people, but also on how they can help us. It’s important to see aging in a different light,” she says. “I truly believe the possibilities are endless with what we can do to empower older people to engage with our University, live longer and healthier lives, and ensure that everyone can age with vitality.”

vital DISCOVERY

The longest-living mammals on Earth, bowhead whales, can live more than 200 years.

In their lab on the University’s River Campus, a research team led by professors of Biology and Medicine Vera Gorbunova, PhD, and Andrei Seluanov, PhD, is studying cells in biopsied tissue from these giants of the ocean to uncover their secret to longevity. Their research into the mechanisms of longevity and genome stability goes back nearly 20 years and aims to solve one of the biggest mysteries of biology: aging.

The goal: Slow aging, slow disease.

“Aging is a risk factor for many diseases that are afflicting mankind. So, if we could slow down aging, we also would slow cancer, dementia, cardiovascular disease, and other conditions that increase with old age,” says Gorbunova, who is the Doris Johns Cherry Professor and co-director of the Rochester Aging Research Center.

“If we succeed to slow aging or improve the process of aging, then we will be able to delay many diseases,” Seluanov adds.

Their lab is part of the Vital Discovery pillar of the UR Aging Institute (URAI). In this area, basic and clinical researchers work to study longevity and the causes and conditions of aging—from basic science to translational studies to health care policy.

“We are building a strong research infrastructure that will translate scientific discovery into clinical care,” says URAI Director Annie Medina-Walpole, MD. “We’ll ask how and why we age and what factors determine longevity, life span and health span, and what interventions can be used to promote health, well-being, and vitality. This is how we’ll expertly care for the growing population of older patients in our region. And, finally, can we slow down the aging process itself, which can be viewed as the ultimate preventive medicine?”

At the Bench

In addition to bowhead whales, which are efficient at genome maintenance and DNA repair, Gorbunova and Seluanov study a variety of long-lived animals such as naked mole rats, beavers, squirrels, and bats. They, too, live long and have evolved unique molecular mechanisms of longevity and disease resistance. Bats, for example, have a unique immune system that is resistant to inflammation, a big driver of age-related diseases.

The lab is a pioneer in comparative studies on aging, focusing on short- and long-lived animals. Its studies of Eastern gray squirrels (average lifespan: 24 years) and naked mole rats (32) have found additional pathways to putting the brakes on aging. For example, they’ve identified an important gene for longevity in the naked mole rat that, when transferred to mice, increases their longevity as well. Cancer incidence typically increases with age, but these long-lived animals naturally resist it. Studying the mechanisms of that resistance has led to new insights that will soon be tested on humans at Wilmot Cancer Institute.

“The process of discovery is really amazing,” Seluanov says. “That’s what is fun. But in addition, we can apply that discovery to improve human health and help people. What can be better than that?”

When molecular biologist Dirk Bohmann, PhD, and his research team were recruited to URMC from the European Molecular Laboratory in 2001, he was using fruit fly genetics to understand how cells defend themselves against effects of environmental stressors such as toxins or radiation.

“It was clear that the ability of an organism to fend off these challenges wanes with age, contributing to the loss of resilience and fitness, thereby increasing the probability of disease and death. But it was unclear at a cell and molecule level why this happens,” says Bohmann.

At the time, the University hosted the Nathan Shock Center of Excellence in Basic Biology of Aging with a grant from the National Institute on Aging (NIA). Bohmann received a small pilot grant from the center to apply his work to aging. High-level publications and funding from the NIA followed, transforming his group into a leading aging research lab.

Team members have gone on to become eminent researchers in their own rights.

The fact that long life is a trait that can run in families suggests—and a lot of research confirms—that aging is not simply the result of a randomly determined, inexorable grindstone, but is influenced by genetics. This can explain the differences seen in older adults as they age.

Hundreds of genes that influence aging have been identified in studies on a small earthworm known as caenorhabditis elegans. Many of these genes exist in humans, yet whether or how they will influence aging in humans is poorly understood. Studying how these genes function in model organisms, such as in earthworms, fruit flies, or rodents, provides insight into how to promote healthy aging in humans. The laboratory of Andrew Samuelson, PhD, associate professor of Biomedical Genetics, is using the worm to explore the fundamental mechanisms by which aging genes act, and how they may dictate lifespan, health span, and the onset of specific age-associated illnesses such as Alzheimer’s disease.

From the Bench to the Bedside

Because of the Institute, collaborations that bring basic research into the clinical setting are multiplying. Gorbunova and Seluanov, for example, are working with clinical scientists at Wilmot Cancer Institute to treat older patients suffering from the side effects of chemotherapy.

And Wilmot works closely with URAI.

More than 60 percent of people with cancer are ages 65 and over, and a third are older than 75. Even though those numbers are expected to rise as the population ages, older adults are severely underrepresented in clinical trials, says Supriya Mohile, MD, the Philip and Marilyn Wehrheim Professor of Medicine and director of Geriatric Oncology Research at Wilmot. Most cancer trial participants are in their fifties and early sixties. Resulting treatments are designed for younger adults who don’t have many of the challenges that come with older age, such as with memory, mobility, and multiple medications.

In every step of the design, they’re partnering with patients.

It’s not ‘no,’ it’s ‘how.’ -Supriya Mohile

Still, the field of geriatric oncology has grown dramatically since Mohile’s training in the early 2000s, particularly in the last decade as clinicians and researchers try to understand the risks and benefits of treating cancer in older people, she says.

Like much of the work done in the URAI, the geriatric oncology clinic at Wilmot, founded by Mohile and led by Allison Magnuson, DO (’02, Flw ’13, Flw ’14, MS ’20), associate professor of medicine, combines research with patient care. SOCARE—Specialized Oncology Care and Research in Elders— is recognized in the U.S. and abroad for providing the most comprehensive, evidence-based care for patients age 70 and older. With a team of six geriatric oncologists, it’s the largest clinical group of its kind in the country.

The opportunity to do translational research while working with patients is a big draw for fellows and residents, and the program is growing from within as a result. Magnuson did fellowships in oncology and geriatrics at Rochester. Now director of SOCARE, she is researching ways to reduce cancer-related cognitive dysfunction, or “chemo brain,” in older patients, who are at greater risk.

Magnuson’s latest research breaks new ground. She received a $2.5 million award from the NIA to study how oncologists can better deliver care to cancer patients who have pre-existing dementia or Alzheimer’s disease. About 7 percent of older cancer patients are in this situation, and current data provide no guidance on whether cancer treatments are safe for these individuals, how to assess the patient’s ability to reason and understand information, and how to have difficult three-way conversations between doctor, patient, and the patient’s representative when complex treatment decisions must be made. Magnuson plans to adapt and test an existing geriatric assessment tool for use in these cases.

Vice Chair for Basic and Translational Science Laura Calvi, MD, holds an NIA-supported $2.3 million grant focused on the mechanisms by which the bone marrow ages. This is significant because abnormal mature cells in the bone marrow can cause inflammation and bone loss, and can support the development of leukemia and other blood cancers. Calvi, who holds professorships in the departments of Medicine; Pathology and Laboratory Medicine; Pharmacology and Physiology; and the Cancer Center, is working with the Center for Musculoskeletal Research to understand how phagocytosis of dead and dying cells affects bone aging.

Kah Poh Loh, MBBCh (Flw ’18, Flw ’19), a hematologist, oncologist, and geriatrician, develops ways for older cancer patients to use digital technology, such as mobile apps, for behavioral and supportive care interventions. Before launching an app-based trial, for example, she consults with older patients on user-friendly design—from font size to information flow. Loh and two other Wilmot Cancer Institute researchers, Michelle Janelsins-Benton (MS ‘05, PhD ‘08, MPH ’13), associate professor of Surgery, Radiation Oncology, and Neuroscience, and Paula Vertino, PhD,

professor of Biomedical Genetics and of Pathology and Laboratory Medicine, were awarded the inaugural UR Aging Institute pilot grant this past year.

“In every step of the design, they’re partnering with patients. It’s not ‘no,’ it’s ‘how,’” Mohile says. “They’re doing really interesting work, and they’re rising stars nationally.”

Eight to 10 geriatrics professionals and students come from around the world every year for SOCARE’s visiting scholars program. After they return home to start clinics and research of their own, they replicate what they’ve learned with ongoing guidance from Wilmot colleagues.

Alzheimer’s Disease, Dementia, and Dementia Care

A new T32 training grant from the NIA will support six PhD students each year who are studying Alzheimer’s disease and aging, says Kerry O’Banion, MD, PhD (Flw ’91), vice chair and professor in the Department of Neuroscience. O’Banion and Gorbunova are co-principal investigators on the five-year, $1.44 million grant.

Participants will study the basic biology of aging and neuroinflammation, attend weekly seminars, and shadow staff in the Department of Psychiatry’s Memory Care Clinic.

“The unique aspect is that PhD students seldom get to see the translational or clinical side that their research in, for example, mice might impact,” O’Banion explains. “You could call it a more holistic view of the challenge.”

The grant confirms Rochester’s strengths in Alzheimer’s disease research, he adds. “It’s recognition that this is a place for training the next generation of investigators in this area.”

More than 400,000 adults over age 65 in New York have dementia, and nearly 600,000 family caregivers provide 835 million hours of unpaid care every year, according to the Alzheimer’s Association. URMC has tapped into this need with a host of programs devoted more broadly to dementia and dementia care, as well as geriatric mental health and well-being. In these clinics and centers, translational research and patient care go hand in hand:

■ The Memory Care Program focuses on neurodegenerative conditions that affect adults and the aging nervous system, such as Alzheimer’s disease and other forms of dementia. Patients receive diagnosis, treatment, and ongoing care. It opened 30 years ago and is the only program of its kind in upstate New York that is part of a psychiatry department. The University of Rochester also has the only geriatric psychiatry fellowship program in upstate New York.

“We have many clinical trials going at once and are a major site for testing of new treatments for Alzheimer’s disease, including monoclonal antibodies,” says Elizabeth (E.J.) Santos, MD (BA ‘94, Flw ‘06, MPH ‘13), associate professor of Psychiatry, Neurology, and Medicine, and clinical chief of the Division of Geriatric Mental Health and Memory Care. “Our expertise in caring for patients with dementia is recognized nationally and internationally.”

■ AD-CARE —The Alzheimer’s Disease, Care, Research, and Education program is led by Anton Porsteinsson, MD (Res ’93), the William B. and Sheila Konar Professor of Psychiatry. The lab participates in international studies in Alzheimer’s disease prevention, cognitive impairment, diagnostic tools, and behavioral disturbances. AD-CARE is co-located with the Memory Care Program, allowing access to world-class clinical care and opportunities to participate in cutting-edge research.

■ The Rochester Roybal Center for Social Ties & Aging Research, also known as Roc STAR Center, is one of 135 Roybal Centers funded by NIA. The Roybal Center program focuses on the translation of discoveries from basic behavioral and social research into effective interventions to improve the lives of older people and assist institutions in adapting to the aging of our society. The Roc STAR Center, supported by a $3.6 million grant, is the only Roybal Center focused on the loneliness and social isolation of caregivers of a family member with dementia.

Research has shown that loneliness increases risk for chronic disease and mortality as much as smoking, obesity, and a sedentary lifestyle. Despite this, there are few scientifically developed interventions to improve social connectedness. “Our work aims to fill this critical gap,” says Kathi Heffner, PhD, co-director of the center and the Marie Curran Wilson and Joseph Chamberlain Wilson Professor of Nursing, professor of Medicine and Psychiatry, associate chief of Research for the Division of Geriatrics & Aging, and a member of the URAI’s executive committee.

Through pilot fund research grants, the Roc STAR Center is building a person-centered portfolio of interventions that community organizations and long-term care facilities can offer struggling caregivers. For example, the center is collaborating with the Geriatric Workforce Enhancement Program education series to develop Connections Planning, an online training module for long-term care providers and staff to treat and prevent loneliness and isolation in older adults.

Loneliness among older adults happens, but it is not the norm, says co-director Kimberly Van Orden, PhD (Flw ’10). “In fact, most older adults experience increased psychological well-being and satisfaction with relationships as they age. Social connectedness is actually an aging-related strength that can be capitalized upon to promote well-being.”

■ NEW Brain Aging Center—The Network for Emotional Well-Being and Brain Aging opened in 2021 with a $2.5 million NIA grant. It is a collaboration among five partners, including URAI and colleagues at Duke, UC Santa Cruz, Johns Hopkins, and Stanford universities. Researchers are studying how an aging brain affects emotional well-being in older adults, and how emotional well-being affects brain function and cognitive aging.

■ HOPE Lab —The Helping Older People Engage Lab conducts randomized clinical trials to discover ways to increase social connectedness and improve well-being through older age.

■ HARP—The Healthy Aging Research Program is a multidisciplinary clinical and behavioral research collaborative to promote healthy aging. HARP partners with the Roybal Center, HOPE Lab, and the Elaine C. Hubbard Center for Nursing Research on Aging, as well as community organizations serving older adults, to help investigators design and implement clinical research studies with older adults.

■ The Stress and Aging Research Lab conducts basic clinical research on the ways in which stress and emotional well-being impact older adults’ immune systems and health outcomes, as well as randomized clinical trials of stress interventions to promote healthy aging.

Much to Learn

Geriatric psychiatrist Yeates Conwell, MD, studies suicide in older adults and is a lead investigator on the NEW Brain Aging Center’s recent grant. Suicide is the bleakest outcome, he says, but it has a lot to teach us about well-being. Studies show older people are on the whole more satisfied with their lives than young and middle-age people. Suicide is a stark reminder that some older adults cannot mobilize the resources that most of their peers can. So what went wrong?

“The work we do is helping older adults through physical and mental disorders and tough times, but at the same time I learn so much from them—about issues like resilience, stress management, and life experience,” says Conwell, professor and vice chair, of the Department of Psychiatry who directs the Geriatric Psychiatry program and is on the URAI’s executive committee. “My work is driven by the fact that we have so much to learn from older people.”

My work is driven by the fact that we have so much to learn from older people. -Yeates Conwell

Solving Real-World Problems

In the URAI’s Vital Discovery pillar, scientists are working closely with clinicians to bring their research into the living laboratory of health care.

A First in Aging Trials

The Gorbunova and Seluanov Lab is working with clinicians in Wilmot Cancer Institute on one of the first U.S. aging trials to come from basic research. In a recent mice trial, they administered a seaweed compound that activates a gene that can reverse aging. It rejuvenates the way DNA is packaged in the cell, carrying an extra dose of a gene that reorganizes mutated DNA strands into a normal configuration. Treated mice showed signs of improved fitness; they ran faster on the treadmill, and their tails became more flexible.

Data Played Out in a Pandemic

Health services researcher Brian McGarry, PT (PhD ‘16), assistant professor of Medicine and Public Health Sciences, studies whether health care systems that serve older adults are really set up to meet their needs. McGarry joins a prominent group of collaborators in the Department of Public Health Sciences, Department of Psychiatry, and School of Nursing engaged in studying the impact of organizational factors and health care policies on outcomes for nursing-home care, acute home-health care, and long-term services and supports their recipients, including veterans, using the CMS, AHRQ, VA, and additional data sources.

Now with Gorbunova, principal investigators Janelsins-Benton and Luke Peppone, PhD (BA ’99, MPH ’10), associate professor of Surgery, Orthopaedics, and Cancer, will use the same compound in a small trial with 32 older adult cancer patients who suffer from the side effects of chemotherapy. Funded by a pilot grant through the URAI, the trial will be one of the first bench-to-clinic trials to look at the fundamentals of aging. If the outcome is encouraging, they’ll test it with healthy participants.

“That’s where the URAI really helped. We weren’t connected to the clinical side before,” Seluanov says. “This type of coordination is really enhanced by having the Aging Institute.”

A regional collaboration also holds promise for research their lab and others do in the URAI. UR is partnering with the University at Buffalo and Roswell Park Comprehensive Cancer Center in early-phase drug development. The New York State-funded Empire Discovery Institute holds promise for translating URAI research efforts into therapeutically viable products, that target longevity genes to extend lifespan and health span to a point where commercial partners can develop them into FDA-approved medicines.

With a new five-year grant from the National Institute on Aging, McGarry will study how older adults with cognitive decline navigate the enormous amount of consumer choice built into Medicare. In his previous work as a physical therapist, McGarry saw firsthand how hard it was for patients to figure out. Now he studies how public policies are put into practice, how they affect the cost and quality of care, and how these policies can help support older adults when they are making difficult health care and health coverage decisions.

He and other researchers in the Division of Geriatrics & Aging meet regularly with clinicians to vet aggregated administrative data, such as claims, to see if it tells an accurate story.

“Most of my colleagues are clinicians working with older adults. I get to sit side by side with them and work on research questions that are pertinent to their practice and their patient population,” he says. “It’s something the Aging Institute embodies—making that connection between the number cruncher/researcher and the clinicians who are living the stuff day to day.”

This collaboration also fuels McGarry’s research into the burden that COVID-19 imposed on nursing homes. In the early days of the pandemic, McGarry did rapid turnaround research for administrators and policy makers—for example, investigating the extent of staff shortages and the time it took to get COVID-19 test results. Now he is studying weekly data from facilities to see how testing might have been done differently to avoid the high number of nursing home deaths.

We weren’t connected to the clinical side before. This type of coordination is really enhanced by having the Aging Institute. -Andrei Selanov

Brian McGarry, PT, PhD

Besides dampening demand for nursing home care, which has long-term implications for the industry, the pandemic took the lives of more than 150,000 residents in the United States. McGarry says this fact alone fuels his work, so his colleagues can prepare for the next outbreak. “That’s important to me. What could be done better? And what, from a systematic standpoint, could make nursing homes safer for the staff who work there and the residents who live there?”

The answer to that question is the driving force behind high quality, age-friendly care at our regional hospitals and nursing homes. Kevin McCormick, MD, PhD (Res ’96, Flw ’98), professor of Clinical Medicine, is leading regional efforts in geriatrics as the medical director of Jones Memorial Hospital in Wellsville, N.Y.

UR Medicine Geriatrics Group (URMGG), led by Dallas Nelson, MD (Res ’03, Flw ’05), associate professor of Medicine, provides comprehensive care to some of our region’s most frail older adults in 12 skilled nursing facilities and 33 assisted and independent living facilities, while Santos, Adam Simning, MD, PhD, assistant professor, and others in the Department of Psychiatry’s Geriatric

Mental Health and Memory Care Division provide telemental health services and supports to residents and staff of about 90 nursing facilities across the state of New York.

The COVID-19 pandemic provided unprecedented opportunities for crisis management and leadership within URMC, the Rochester community, and its surrounding regions; including the care of nursing home residents with COVID-19 infection, delivery of vaccines, boosters, and monoclonal antibody treatment; transition to telemedicine visits; and outbreak testing.

McGarry; McCormick; Nelson; and Ryan Gilmartin, MHA , URMGG senior program officer, along with many other UR Medicine faculty and advanced practice providers, rose to this incredible challenge and exhibited extraordinary commitment, leadership, and expertise to coordinate and improve our community’s response to the COVID-19 pandemic. (See photo on page 26.)

vital CARE

For older people, falling and breaking a hip is a sentinel moment. For some, it marks the beginning of the end.

In 2004, a team of orthopaedists and geriatricians at Highland Hospital saw an opportunity to change that trajectory. Realizing that medical issues that complicate later-life surgery weren’t being addressed, they created a model of geriatric fracture care that would be replicated around the world.

The Geriatric Fracture Center at Highland, developed by Daniel Mendelson (MD ’95, Res ’98, Flw ’00), clinical professor of Medicine, and now directed by Corey Romesser, MD (Res ’06, Flw ’07), associate professor of Clinical Medicine, screens patients with fractures for specific age-related surgical risks, such as medication interactions or delirium. Patients have beds in the orthopaedics unit, where staff are trained in geriatrics care, and are fast-tracked to surgery (within 24 hours of admission). They have fewer complications, such as pneumonia, and are up and walking sooner.

“That’s something you can do in a community hospital with connections to an academic medical center. It’s a really great example of optimal care,” says geriatrician Robert McCann, MD, former chief of Medicine at Highland and CEO of Accountable Health Partners, URMC’s clinically integrated network of hospitals and physicians.

Institute’s (URAI) Vital Care pillar. Guided by the AFHS model, together they focus on education and multidisciplinary patient care.

The Extension for Community Healthcare Outcomes (Project ECHO®), a video-based mentoring model, reduces health disparities by bringing specialist expertise to frontline staff who work in underserved communities.

Robert McCann, MD

In addition to designing a better way to treat fractures in older people, the center has spawned a journal and several dozen publications. Doctors in the center have traveled to at least 30 countries to share their knowledge and methodology. They are developing a national teaching program to expand these and a database documenting treatment and outcomes around the country.

In 2017, the Geriatric Fracture Center at Strong Memorial Hospital was launched as a model of co-management among hospital medicine, geriatrics, and orthopaedic surgery. Directed by Jenny Shen, MD (Res ’13), assistant professor of Medicine, this fracture center models the original Highland Hospital-based center—with equally successful patient care metrics and outcomes. “Sharing best practices among our own providers and other Age-Friendly Health System (AFHS) institutions will result in the best, most consistent care possible.”

The Geriatric Fracture Center is just one of dozens of programs in the UR Aging

Under the leadership of Michael Hasselberg (MS ’07, PhD ’13), and Elizabeth (E.J.)

Santos, MD (BA ‘94, Flw ‘06, MPH ‘13), URMC chief digital officer, the University of Rochester launched Project ECHO® Geriatric Mental Health, targeting primary care offices throughout New York state. This model was soon extended to more than 100 nursing homes throughout the Greater Rochester region and the state to improve geriatric behavioral health and successfully reduce the use of psychotropic medications in nursing homes. That sparked creation of a full geriatric telepsychiatry program to support multidisciplinary teams working in nursing homes and rural hospitals.

Educating the professional workforce, current and former fellows and program leaders from the divisions of Geriatric Medicine and Psychiatry include, from left: Fatima Hafizi, MD; Thomas Caprio, MD; EJ Santos, MD, MPH; Lisa Vargish, MD; Brigid O’Gorman, MD; Naveen Silva, MD; Sindhu Kadambi, MD; Jennifer Muniak, MD; John Seymour, MD; Kate McBride, MD; Jacqueline Quezada, MD; and Adam Simning, MD.

Learning Curve

Workforce education creates channels for spreading best practices and care models for older adults in hospitals, nursing homes, and clinics. Disciplines come together to research and treat conditions in a way that is tailored to the needs of older patients.

A spirit of creativity and curiosity is essential for this kind of collaboration to thrive, but that rarely pops up out of nowhere. Layered underneath is an educated workforce, which brings people together in a united cause.

Having staff with the knowledge and skills to care for an aging population is nothing short of a system transformation—and long overdue, says geriatrician Thomas Caprio, MD (Res ’03, Flw ’05, MPH ’10, MS ‘15). Caprio is principal investigator of the University of Rochester Geriatric Workforce Enhancement Program (GWEP), now in its second round of funding with a $3.7 million grant from the Health Resources and Services Administration (HRSA) to support URMC’s Finger Lakes Geriatric Education Center, which Caprio directs.

“There aren’t enough geriatricians in the country,” Caprio says. “We’re pushing out the appropriate education and training across all professionals so they are sensitized to the unique challenges and risks of older adults, so they can provide the best care possible. It’s sort of geriatricizing the health care system.”

UR geriatrics has developed an excellent national reputation. Many of the most well-known geriatricians have trained there. -Rosanne Leipzig

Training is for all kinds of health care professionals, and they learn together in an interprofessional approach—from physicians, nurses, nurse practitioners, physician assistants, and pharmacists to therapists, dietitians, and students of all disciplines. Issues discussed relate to the Four Ms of the AFHS (see page 19), addressing everything from cognitive changes and loneliness to medication and advanced-care planning.

The workforce enhancement grant also funds training to help age-focused nonprofits and primary care practices diagnose dementia and other cognitive conditions. And spurred by the pandemic, online and videoconference trainings have exploded, reaching more than 15,000 professionals across the state and nation.

The GWEP grant was the first in the state to use Project ECHO® for geriatric training. In this case, it links URMC geriatrics specialists with doctors, nurses, social workers, pharmacists, and others at 60 nursing homes in the Finger Lakes region. Sessions cover geriatric behavioral health, the AFHS, and quality improvement and patient safety related to the COVID-19 pandemic.

The School of Medicine and Dentistry is one of very few that emphasize an aging curriculum from the first year to fellowship, and it is even taught to undergraduates. Its foundation is in the biopsychosocial model, which treats the person and not just the disease. An integrated aging theme instilled geriatrics into all four years of the undergraduate medical curriculum and is replicated nationally. Students continue with early exposure to older adults in clinics, hospitals, and nursing homes to battle ageism and ensure competency in nationally established geriatrics training benchmarks.

“On Day One of medical school, 100 students listened attentively as a geriatrician sat down with a geriatric patient and showed us how to talk to an older patient,” recalls Heather Hopkins Gil (MD ’12, Res ’15, Flw ’16), a geriatrician and palliative medicine physician at Northwestern Medicine in Chicago.

“Rochester’s training for geriatrics is integrated so well that you do not always realize you’re learning fundamental geriatric medicine,” she adds. “This is critical because the majority of patients admitted to hospitals or facing serious illness are older or frail.”

Groundbreaking geriatrics educator Rosanne Leipzig, MD, PhD (Res ’82), vice chair for Education in the Department of Geriatrics and Palliative Medicine at Mount Sinai’s Icahn School of Medicine, says her Rochester geriatrics residency training pushed her to be the best clinician possible.

“All medical residents spent at least six weeks at Monroe Community Hospital, and with T. Franklin Williams,” she says. “UR geriatrics has developed an excellent national reputation. Many of the most well-known geriatricians have trained there.”

The Beauty of Co-Management

The Geriatric Fracture Center is a geriatric co-management model at URMC that has been replicated around the world to improve patient outcomes in a cost-effective way. It’s the kind of thing the UR Aging Institute (URAI) is ideally suited to help foster. Others include Geriatric Trauma Surgery at Strong, led by Ciandra D’souza, MD, MPH, assistant professor of Medicine; and Geriatric Oncology at Highland, led by Corey Romesser, MD (Res ’06, Flw ’07), associate professor of Clinical Medicine.

URAI is also helping to partner the Division of Geriatrics & Aging with colleagues in surgery, hospital medicine, anesthesia, and nursing so that every older adult undergoing surgery has the same high-quality standard of care. A work group is spearheading efforts to prepare for geriatric surgery verification from the American College of Surgeons, under the leadership of Gabriella Poles, MD, MPH, assistant professor of Surgery, and Heather Lander, MD, assistant professor of Anesthesiology. Poles and Lander are both former Geriatric Faculty Scholars.

Growing Geriatrics and Aging

To enlarge the ranks of geriatrics and aging specialists and researchers, the University is teaching the next generation through a network of programs under the UR Aging Institute umbrella. Clinical training is through the Department of Medicine’s Division of Geriatrics & Aging, the Department of Psychiatry’s Division of Geriatric Mental Health and Memory Care, Finger Lakes Geriatric Education Center, the Geriatric Medicine and Psychiatry Fellowship Programs, and the School of Nursing Adult Gerontology NP Program. Basic research in labs on both campuses includes undergraduates to postdocs.

And training is not just in the sciences: The Warner School of Education offers coursework and research opportunities in aging, such as mental health; cognitive development; and the social, cultural, and historical influences on individual development in late life.

Quality Improvement

As a geriatrics educator focused on hospital and long-term care, Jennifer Muniak, MD (BS ’06, Res ’13, Flw ’15), assistant professor of medicine, is invested in equipping health care workers with the skills to treat older patients. But how well it works in practice must be quantified, she says.

“Our population is aging, and older adults are interfacing with a health care system that was not designed for them. To find a way forward for all older adult patients, doctors need the skills to look at data critically and change systems of care based on the problems we see,” she says.

Muniak recently received the highly competitive Geriatrics Academic Career Award, a four-year career development grant from HRSA for junior faculty. One of only 26 national recipients, she studies quality metrics data to get a sky-view of how well hospitals and nursing homes care for their older patients, using AFHS benchmarks. The data are voluminous, she says, and as technology takes over, she worries patient stories could be lost.

During the pandemic, AFHS was a lifeline for hospital workers and the many older patients in their care who had the virus. Tested under fire, AFHS and the Four Ms are spreading in URMC doctors’ offices, hospitals, and nursing homes around the region. In the Age-Friendly Health System Work Group, URMC specialists from multiple departments, Strong Memorial and Highland hospitals, Eastman Institute for Oral Health, and the Center for Perioperative Medicine are mapping their rollout.

The need is dire: Only 3 percent of social workers, psychologists, doctors, and other professionals choose a geriatrics specialty. Fellowships go unfilled. But older adults account for 31 to 36 percent of inpatient

Delirium Antidotes

Highland Hospital has a wealth of geriatricians on staff from the Division of Geriatrics & Aging—more than all other Rochester area hospitals combined—so it’s uniquely suited to address issues related to the stress of hospitalization from an older person’s perspective. Two nationally replicated, evidence-based initiatives show how Highland is helping to prevent delirium, the most common complication for older hospital patients. Studies have shown that a third of patients over 70 experience some level of this disorienting condition.

■ Acute Care for Elders Unit (ACE)

Teams of social workers, nurses, doctors, advanced practice providers, and occupational, speech, and physical therapists meet with patients and their families in a continuous quality improvement model of care to prevent functional decline during hospitalization. Individualized care plans are tailored to patients’ needs. For example, IVs and catheters are removed as soon as possible, allowing patients to regain mobility, which is important for healing.

• Hospital Elder Life Program (HELP)

“We have to think about how we care for older adults at the population level, looking at big data and using quality improvement methods; the challenge is that now, more than ever, patients need medical care that is tailored to the nuances of their individual circumstances. That’s where the skillsets of geriatricians thrive—structuring systems of care in such a way as to keep what matters most to patients at the center of each patient’s care.”

Geriatricians have an opportunity to take leadership in this new space, Muniak says.

“We can offer that perspective. We can keep helping build all these tools and the big data sets to decide what to track and to keep that patient perspective at the forefront.”

encounters at Strong Memorial and Highland hospitals, and up to 30 percent of outpatient visits. That was more than 485,000 patient encounters in 2021, and it’s on the rise.

“Every health care professional in every discipline needs the skill set to provide high-quality care for older patients,” says Annie Medina-Walpole, MD, director of URAI. “And the Age-Friendly Health System is something that people can grasp. It is the driving force of our Vital Care initiatives in the Aging Institute. We will make Rochester the healthiest place to age in America.”

Volunteer pre-med and pre-nursing students, as well as volunteers from the community, visit patients over age 65 in this comprehensive program designed to prevent delirium and functional decline. Through daily visits and activities, nursing education, and focused attention to hearing, vision and sleep, Highland has achieved a reduction in important areas, such as falls, delirium, and length of stay.

Jennifer Muniak, MD

We will make Rochester the healthiest place to age in America. -Annie Medina-Walpole

vital

Martha Hope isn’t one to sit at home all day with nothing to do. Well-occupied from a young age, she had a long career in human services and foster children to raise.

But one day, some time after her husband had passed away, she sat in her bedroom and started to weep. Until that moment, it hadn’t dawned on her that she was lonely.

“I realized what was happening, so I started talking to people. I said, ‘We need to talk about this isolation and being lonely.’ I’m concerned about mature adults. We can’t assume that everybody is happy by themselves,” Hope says.

Hope, who is nearly 80, found her way back by following her interest: connecting people. She and Charles White, whose own struggle with loneliness and depression during the pandemic spurred him to get involved, organized social events for older adults last year—an Erie Canal cruise, a trip to Onondaga Lake to see the holiday lights—and the nonprofit Senior Expressions was born.

“We try to address isolation, mental health challenges, depression, and anxiety that we see in our seniors, especially single seniors that may not have that outside connection,” White says.

When the organization held a semiformal ball at Harro East last year to bring everyone together, the UR Aging Institute stepped up to assist and was invited to participate. In addition to dinner and dancing, the ball featured tables staffed by University specialists who provided information about resources—at the University and in the community—for older adults. The ball was a hit by all accounts, and a second this year was equally successful.

“When I think of aging with vitality, the first person who comes to mind is Martha Hope. She, along with Charles White, has been an inspiration to me personally and a driving force behind the Institute’s engagement with the Rochester community,” says Annie Medina-Walpole, MD, chief of the Division of Geriatrics & Aging and director of the UR Aging Institute (URAI). “Partnering with Senior Expressions has allowed us to connect with older people to promote education, health, and safety. We look

forward to many more years of collaboration, and I am excited to see where this new partnership takes us.”

Supporting the Experts

Being involved in the ball was part of URAI’s Vital Living pillar, which steers its research, education, and patient care outward to help create an age-friendly community in Rochester. It starts with a simple question: What does it mean to age with vitality? It finds the answers through the wisdom of older adults and the expertise of area organizations.

Rochester has rich resources for older people. The Monroe County Aging Alliance illustrates this well. More than 20 member organizations—from aging providers to businesses—advocate on issues facing older adults, including poverty, ageism, and livable community initiatives. They recently created and published an action plan for an Age-Friendly Rochester and Monroe County.

It’s a relatively small city—210,000, with 1 million in the six-county region—but large enough to be an innovative model for an age-friendly community. People 65 and older make up 17 percent of the county population, a number expected to rise.

There’s a lot of work ahead. Income disparities force a wide gulf between the highest average life expectancy in the county (81.1 in Pittsford) and the lowest (72.4 in the city’s southwest quadrant). A 2021 report by the Alliance, Poverty in Later Life, showed that one in five city residents age 65 and older lives below 100 percent of the poverty level ($12,490 per year). The number of poor adults in the city is growing.

And while the University has a strong history in geriatrics and many partners in the community, work remains “to make the University and Medical Center truly collaborative and trusted by the community,” says geriatric psychiatrist Yeates Conwell, MD.

In 2003, Conwell and psychiatry faculty colleague Carol Podgorski, PhD, started exploring ways to improve mental health services for local older adults. With a five-year grant from the National Institutes of Health, they created SHARE—the Senior Health and Research Alliance—together with Lifespan of Greater Rochester, an advocacy and aging services organization for older people and caregivers, and Catholic Family Center.

“We turn to those agencies to really learn what is important to older adults. Lifespan is working out there on the streets every day. They’re the real experts in that. And in turn we can show them how to study the effects of the programs they offer,” Conwell says.

Their research showed that older adults with mental health issues rarely sought those services. Through SHARE, the agencies started focusing on data and evidence-based practices, which gave them the information they needed to build an infrastructure that better meets the mental health needs of their constituents, Podgorski says.

Other programs have multiplied since SHARE began, and faculty are surveying the current mental health landscape for an update. The institute is keen on avoiding duplication.

“We either want to add value or fill in gaps or find ways to enhance those services with things universities do best,” Podgorski says.

A sampling of other programs includes:

■ HOPE (Helping Older People Engage) Lab is working with Lifespan and other partners to ease the loneliness of people and their family caregivers. Led by Kim Van Orden, PhD, and with funding from the National Institutes of Health and other sources, the lab is developing a portfolio of interventions that agencies can use to help boost social connectedness in later life. For example, peer-support programs, like the Retired Senior Volunteer Program, help reduce isolation and improve quality of life for lonely older people.

■ FLCEAD (Finger Lakes Center of Excellence for Alzheimer’s Disease), led by Podgorski, works to expand the reach of services for people with cognitive impairment. A big part of this is outreach to rural and minority communities. The number of referrals for dementia screenings the center receives outstrips capacity, so FLCEAD is working with other UR partners to educate primary care doctors to screen in their practices. URMC’s Memory Care Program is the clinical hub for FLCEAD.

Showing Up for All Nurse Practitioner

Ida Earner Ida Earner (BS ‘99, MS ‘09), was named a University DEI champion in the Division of Geriatrics & Aging last October and, in June, received the division’s inaugural Community

Engagement Award. Born and raised in Rochester and the daughter of Mexican immigrants, she focuses her efforts on equitable health care in the community where she grew up. Latinx adults age 65 and older have the highest poverty rate in Rochester (39 percent)—nearly twice that of Black adults of the same age.

As Earner and her colleagues give presentations on health topics in the community, one event hit especially close to home. The Division of Geriatrics & Aging and URAI were invited to present at the monthly meeting of Centro de Oro, a 60-and-older Spanish-language social group affiliated with Ibero-American Action League. The event was held at Jackson Recreation Center, adjacent to School No. 9, the school Earner attended. Earner, Medina-Walpole,

and Marie Bell (EdD, RN ’94, GNP-BC), a nurse at Strong Memorial Hospital and nurse practitioner with the UR Medicine Geriatrics Group who previously worked with Centro de Oro, shared home safety tips for preventing falls, taking medication, and handling scam phone calls. Then someone mentioned Earner had been a local student. That brought the house down.

“Oh my goodness! It was a great feeling to be back,” she says, laughing. “It was really awesome to come full circle.”

It’s important to walk the walk, adds Earner, who recalls translating her father’s Spanish during his hospital stays. “We talk so much about addressing these disparities in access to care. It’s not until they see us physically out there, going into these communities, that they’re going to understand this is a mission, not just a checkbox.”

Blanca Valdovinos, MD

During her fellowship for movement disorders, neurologist Blanca Valdovinos (MD ’15, Res ’19, Flw ’20), assistant professor of Neurology and Geriatric Faculty Scholar, noticed that

only two Spanish-speaking patients came through the clinic over the course of a year. Latinx make up 20 percent of Rochester’s population. With such a discrepancy, she knew it had to be an access issue.

That spurred Valdovinos, a second generation Mexican-American, to start a neurology clinic for geriatric Spanish speakers. She mostly sees patients with Parkinson’s disease, but also treats more common neurologic illnesses, like headaches and migraines. She thought it would take a while to catch on but, by the

end of the first month, she was booking out four months. That has since expanded to a six-month wait.

“There’s a huge, huge need that we’re trying to meet but haven’t yet,” she says.

Valdovinos has found that her older-adult patients whose first language is other than English can feel isolated. They may be uncomfortable talking about their concerns with a doctor, feeling rushed or misunderstood.

About a year into the clinic, Valdovinos applied for and received a Geriatric Faculty Scholar award from the Division of Geriatrics & Aging, funded by the Geriatric Workforce Enhancement Program grant. A main goal is to educate nurse practitioners, nurses, residents, and fellows who rotate through the clinic. Hour-long sessions based on the AFHS 4Ms equip them with ways to get around language, mistrust, and cultural barriers. And her Spanish-only patients use a special diagram to convey what matters most to them.

Preliminary findings show that patient trust has improved, along with how well patients feel their doctors know them. “I know we are making changes little by little, by being more mindful about ‘how do I take care of a geriatric patient? How do I approach them?’” Valdovinos says. “I also think it’s made me a better doctor.”

Learning Loop

In a learning feedback loop with the University, older adults become advocates, teachers, and researchers themselves.

“We want to learn from older adults,” says Podgorski. “We want them to engage across our University. We want to find what they might have to teach us, what matters to them, whether through knowledge, program development, or shaping health promotion programs.”

Engaging Older Adult Learners as Health Researchers (ENGOAL) was a great example of this in action. It is a year-long certification program in health research skills, through the Warner School of Education, for older adults from underserved communities. They learned about chronic illnesses so they could advocate for themselves, as well as convey the perspective of their communities’ values and priorities more

effectively to health professionals. They also partnered on projects with geriatrics researchers at UR. Silvia Sörensen, PhD, a gerontologist and associate professor of human development at the Warner School, was project lead.

Charles White was diagnosed with multiple sclerosis in 2016 and earned ENGOAL certification in 2019. The road to that day was a long struggle made worse by racial bias in the health care system.

Before his diagnosis, White spent years confused and in pain, trying to find help. With no insurance, he’d seek relief in hospital emergency departments, where he was often assumed to be under the influence of drugs or alcohol and left alone. Even after his diagnosis, he didn’t understand how to manage his condition, and he had no idea how to navigate the health care system to find out.

White shares his story today with third-year medical students to drive home lessons in bias toward people of color in medical care. And he is a liaison between the Department of Neurology and community members—many of whom do not trust the medical establishment—to improve engagement, education, patient care, and wellness. For example, he is collaborating with researchers to present community workshops on ways to boost brain health through a nutritious diet—and how to overcome barriers to access to healthy food.

This kind of paradigm shift is possible in an age-friendly university, says Medina-Walpole.

“We need to encourage older adults to participate in education and research, and promote personal and career development in the second half of life. The possibilities here are truly endless,” she says.

Ryan Gilmartin, MHA , program administrator for URAI, the Division of Geriatrics & Aging, and UR Medicine Geriatrics Group, and a member of the URAI executive committee, says the work comes from a place of genuine intention.

“I couldn’t be more proud to work where I work,” says Gilmartin. “Our institution wants to be the best it can be, not only for UR but really for the Rochester community, which gives me a great deal of pride, being a community member myself,” he says. “As the health system has evolved and expanded farther out, it’s really cool that this mission I see and feel in here every day is brought into every community we work in.”

Many of URAI’s leaders are baby boomers who “decided a long time ago they were not going to age like their parents aged. They were going to transform things,” Podgorski adds. “We all have this idea of how we want to age. That’s the exciting thing. Aging doesn’t just mean illness. There’s so much life and creativity in later years. We just have to help people tap into it.”

Baumhauer Cited for Research Achievement

Judith Baumhauer, MD, MPH, medical director of Patient Reported Outcomes, which is housed within the URMC Quality Institute, earned the 2022 Association of Bone and Joint Surgeons Nicholas Andry Lifetime Achievement Award for her work in patient-reported outcome measures. The annual award is granted to honorees whose lifetime body of musculoskeletal research has significantly contributed to the knowledge base and has had a substantial impact on the field of orthopaedics.

Baumhauer has published nearly 200 peer-reviewed papers and book chapters; her current research efforts focus on use of patient-reported outcome (PRO) assessments to measure and manage treatment options for patients. She has led efforts to operationalize PRO collection as a part of clinical patient care throughout UR Medicine.

Baumhauer also has overseen the design and implementation of several clinical trials to bring new, meaningful orthopaedic

products, such as the synthetic cartilage implant Cartiva, through the FDA approval process and into widespread use to advance patient care for great-toe arthritis.

She is a past president of the American Board of Orthopaedic Surgery, the American Orthopaedic Foot and Ankle Society, and Eastern Orthopaedic Association. She is currently president of the PROMIS Health Organization and a trustee for the American Journal of Bone and Joint Surgery. She is also a reviewer for Clinical Orthopaedics and Related Research, Foot and Ankle International, and the Journal of Orthopaedic Research

Baumhauer has won numerous awards for her research and clinical contributions, and is a three-time recipient of the Roger Mann Award for Outstanding Clinical Study, granted by the American Orthopaedic Foot and Ankle Society, and two-time winner of the Goldner Award for Basic Science excellence in research.

Heatwole Tapped to Direct Center for Health + Technology

Chad Heatwole, MD (Flw ’05, Flw ’06) has been appointed director of the Center for Health + Technology (CHeT) at the University of Rochester, succeeding Ray Dorsey, MD, David M. Levy Professor of Neurology, who had led the Center since 2013.

CHeT has played a leading role in the study and approval of many of the medications used to treat Parkinson’s and other neurological diseases, according to Robert Holloway Jr., MD (Res ’93, Flw ’96) , professor and Edward A. and Alma Vollertsen Rykenboer Chair of the

Department of Neurology. Under Dorsey’s leadership, it became a recognized leader and innovator in harnessing digital health technologies—such as telemedicine, wearables, remote monitoring, and mobile apps—to improve access to care and conduct decentralized clinical trials.

Heatwole, a professor of Neurology with a research focus in experimental therapeutics, is sought out by patients from across the country for his expertise in neuromuscular disease and myotonic dystrophy. Since 2018, he has served as associate director of CHeT and director of the center’s Outcomes Measures division. In that role, he has overseen the development of more than 100 patient-centered, disease-specific research instruments that focus on measuring changes in health. These instruments have been translated into 12 different languages and are used by academic, industry, and

government researchers around the globe to measure clinically relevant changes in health in response to therapeutic interventions during clinical trials.

“CHeT’s mission is to advance human therapeutics, patient health, and scientific knowledge,” said Heatwole. “At the heart of our mission is the patient and their families. In partnership with our uniquely talented, skilled, and experienced group at CHeT, we aim to facilitate the development, identification, dissemination, and approval of therapies that are meaningful and improve the daily lives of individuals with complex disorders. This will remain one of our core principles as we strengthen and expand our public, private, and academic research connections; continue to be a leader in technological innovation and outcome-measure development; and grow our University mentorship and training programs.”

Messing Named President of American Urological Association

Edward Messing, MD, professor of Urology, took the helm of the nation’s largest professional association of urologists in May. Messing is the third URMC urologist to hold this post.

A celebrated expert in all facets of urologic oncology, Messing was chair of URMC’s Department of Urology from 1995 to 2018. He has conducted extensive research in the biology of bladder and prostate cancers and been principal investigator on numerous clinical studies for the detection, prevention, and treatment of genitourinary cancers. He is currently studying whether bladder cancer has molecular features that can predict response to gemcitabine, including whether certain enzymes that metabolize gemcitabine rapidly could make cancer cells more resistant.

Messing has held previous leadership positions with AUA and in other national, regional, and local organizations, including the presidencies of the AUA’s Northeastern Section and the Society of Urological Oncology and the interim directorship of the National Cancer Institute-designated

URMC Cancer Center. He is author or co-author of 26 book chapters and 346 urology journal articles and has earned numerous awards, including AUA’s

Presidential Citation and the prestigious Ramon Guiteras Award, as well as the Society of Urological Oncology’s SUO medal and its Distinguished Service Award.

Lee Chosen to Lead International College of Psychosomatic Medicine

Hochang Benjamin Lee, MD, John Romano

Professor of Psychiatry and chair of the Department of Psychiatry, was installed as president of the International College of Psychosomatic Medicine (ICPM) at its 26th World Congress held recently in Rochester.

The organization’s membership hails from more than 30 countries and consists of a broad range of professionals, including internists, general practitioners, pediatricians, nurses, social workers, psychiatrists, psychologists, and other health care providers.

The start of Lee’s two-year tenure coincided with URMC’s hosting of the World Congress of Psychosomatic Medicine. As the birthplace of the biopsychosocial model, Rochester offered an appropriate backdrop for providers from across the globe to gather and discuss the model’s history and impact on patient care today and into the future.

Lee was recruited to URMC in 2017 from Yale University, where he was founding director and chief of the Yale School of Medicine Psychological Medicine Service. He also directed Yale’s Psychological Medicine Research Center.

Lee is certified by the American Board of Psychiatry and Neurology in both Psychiatry and Psychosomatic Medicine.

Quill Book a Tool for Exploring, Understanding VSED

“I have been engaged in research and discussions around medically assisted dying for many years,” said Quill. In New York State, physician-assisted death is not legal, but many terminally ill patients want and need help figuring out what their end-of-life options are. VSED has been a legally available option in the background for some time now, but most people don’t know about it or fully understand it. We wrote this book to help physicians, patients, and families learn about the process from a clinical, legal, and ethical perspective.”

Chapters from the book include several real-patient stories, including a contribution from Robert Horowitz (MD ’93, Res ’98) , URMC division chief of Palliative Care, who details his, his mother’s, and their family’s experience in a way that humanizes this medically and emotionally complicated situation.

Both physicians and patients are often hesitant to bring up end-of-life planning because it is difficult to talk about and because of legal and ethical concerns. Quill’s book approaches the topic with a deep sense of empathy for all involved. It can be a tool for opening up the conversation between family members and/or for a patient to start a discussion with his or her physician.

In his latest book, Professor Emeritus Timothy Quill (MD ’76, Res ’80, Flw ’81) tackles the topic of voluntarily stopping eating and drinking (VSED) in end-of-life care. Voluntarily Stopping Eating and Drinking: A Compassionate, Widely Available Option for Hastening Death provides realistic descriptions of what happens to a person when they consider and potentially choose VSED. Quill addresses misconceptions of this poorly understood practice, which can cause people to inaccurately picture uncomfortable starvation and unrelieved suffering, and asserts that VSED can be peaceful and meaningful when supported by knowledgeable and caring physicians.

Quill is world-renowned for his progressive discussions around palliative care and end-of-life situations. In addition to his clinical role at URMC, he is also a board member of the Death with Dignity National Center in Portland, Oregon. In 2013, Quill was included on a list of “Hospice and Palliative Medicine Visionaries” by the American Academy of Hospice and Palliative Medicine.

Ritchlin Honored by NPF for Lifetime Achievement

Christopher Ritchlin, MD (MPH ’08) , professor of Medicine, has received a Lifetime Achievement Award from the National Psoriasis Foundation (NPF), honoring his long history of research and clinical care.

A founding member of the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis, Ritchlin also is, through NPF, co-chair of the COVID-19 Task Force and a member of its scientific advisory committee.

Ritchlin is director of URMC’s Clinical Immunology Research Unit and a member of the Center for Musculoskeletal Research. He has served as division chief of Allergy, Immunology, and Rheumatology for eight years, growing the division in both size and funding.

“His efforts for the foundation and his larger contributions to the understanding and advancement of treatment for psoriatic arthritis will resonate for generations to come,” NPF noted in presenting the award. “His work has had a profound impact on those impacted by psoriatic disease as well as on the NPF community throughout the country.”

Reunion WEEKEND

School of Medicine and Dentistry alumni from class years ending in 0, 1, 5, and 6 gathered in June for festive Reunion Weekend celebrations. Among the events were a conversation on the future of health care with Jack Rowe (MD ‘70) and Mark B. Taubman, MD, URMC CEO and dean of the School of Medicine and Dentistry; a dynamic alumni panel discussion on the future of medical education; class dinners; and special tours.

Circle

Thomas Tesoriero ’81M (MD) will be the first to tell you how transformational his medical education was here. The quality of the education. The small class size. Faculty members who inspire as much as they educate. As Tom puts it, the University of Rochester's School of Medicine and Dentistry was the cornerstone of his career as a primary care physician.

Tom wanted others to experience the same life-shaping opportunity for growth. He and his husband, Rob, named the medical school as a beneficiary of Tom's retirement assets, establishing a scholarship fund to support medical students who earned their bachelor's degree from a state college or university. It’s a profoundly powerful gift that will change lives.

Renal Pathologist and SMD Instructor Bernard Panner, MD, Dies at 93

Most of his former students and colleagues have stories about the late Bernard Panner, MD (Res ’61), but one in particular involves a doughnut.

David Hicks (MD ’83), was a second-year medical student in Panner’s pathology class at the School of Medicine and Dentistry. As he opened the small blue book, he was met by a red line drawn through his answer to an essay question, marked 50 percent.

“Mr. Hicks,” Panner had written. “If the answer to this question was a doughnut, you would have eloquently described the hole and missed the dough completely.”

Today, Hicks, who says Panner’s teaching and mentorship greatly influenced his decision to become a pathologist, is just one example of many lives he touched during his long and fruitful career spanning nearly six decades at the medical school. Panner died April 20 at the age of 93.

An Ohio native, he was born to Jewish immigrants and came to Rochester after the Korean War, having served as a Navy ship doctor. He was chief pathology resident at Strong Memorial in the late 1950s and stayed for the rest of his career. He specialized in renal pathology, became professor emeritus in 1998, and fully retired in 2017.

Panner is known for being the first pathologist in the Rochester region to use electron microscopy (EM) to examine renal biopsies, using high-powered magnification to diagnose and guide treatment for kidney diseases. This was cutting-edge technology, and these contributions paved the way for more precise patient diagnoses and treatment to this day.

“Bernie was among the first generation of subspecialty renal pathologists,” says Bruce Goldman, MD, who is a renal pathologist at URMC and a longtime colleague. “I don’t think

I have known any renal pathologist who was more informed, thoughtful, disciplined or caring in his diagnostic approach.”

Outside of work, Goldman said Panner, a cellist, recruited him to play in the Penfield Symphony Orchestra. Panner was an avid reader and lifelong learner with a passion for history— especially Talmud and Jewish history. He and wife Molly, who had three sons and 10 grandchildren, hosted many Shabbat dinners at their home in Brighton.

Panner was a wine connoisseur and took pleasure in sharing wines from his personal cellar. “Although he did say more than once that his principal criterion for judging wine was whether or not it conformed to the shape of the glass,” says Goldman. “I really can’t fully express the importance Dr. Panner had in my life, both professionally and personally. I treasure my memories of the time I spent with him.”

While students or others who had heard of his reputation could find him intimidating, those who worked with him say that under the seemingly stern exterior was an incredibly kind, brilliant mentor—who loved to crack a witty joke. He regularly took his staff to lunch and invited their families out to dinner each year.

Steve Coleman, who worked as Panner’s lab technician for nearly 30 years, says he treated

everyone with equal politeness and courtesy, no matter if you were a physician or a janitor.

“He was just someone whom you looked up to and respected because of the way he acted toward everyone,” says Coleman. “The world needs more Dr. Panners in it.”

Karen Vanderbilt, who was the technical specialist in the EM lab leading up to Panner’s retirement, agrees. She remembers his white tea kettle, and unpretentious brown bag lunches he took to work each day. “He just expected the best from you and had high expectations,” says Vanderbilt. “He would include me if he found something interesting in a patient. He was the one I learned it all from.”

While his professional accomplishments were many, he was first and foremost a proud father and grandfather. Vanderbilt recalls, “His family came first, and his job was a very close second.”

Word has reached us of the passing of the following alumni and friends.

The School of Medicine and Dentistry expresses its sympathy to their loved ones. (August 1, 2021 to May 1, 2022)

John A. Frantz (MD ‘46)

Donald Huene (MD ’59)

Daniel J. O’Donovan (PhD ’64)

John (Jack) C. Peachey (MD ’54)

Rosemary Utz (MD ’79)

-Bethany Bushen

Dedicated to Science and the Arts: James V. Aquavella, MD

For more than 60 years, James V. Aquavella, MD —a corneal surgeon and the Catherine E. Aquavella Distinguished Professor of Ophthalmology at the University of Rochester Medical Center’s Flaum Eye Institute—has been a leader in clinical practice, surgery, education, and research. He is known worldwide for his work with artificial corneal implants for infants and

children, which have restored sight to patients as young as a few weeks old.

Over the course of his distinguished career, Aquavella has conducted seminal research; taught and mentored countless medical students and corneal surgeons; given lectures around the world; authored textbooks and published more than 350

papers; and helped and healed many patients and their families.

Aquavella is also a a champion of the humanities, an avid art collector, and a former member of the Board of Managers at the Memorial Art Gallery (MAG). With a strong wish to share his passion for art with the Rochester community, he recently donated

12 paintings from 17th and 18th century Europe and America to the MAG. He and his late wife, Kay—a nurse, educator, and hospital administrator—have gifted a total of 15 works of art to the museum from their private collection.

Aquavella received his AB from Johns Hopkins University and his medical degree from the University of Naples in Italy. Upon his return to the U.S., Aquavella became a member of the health teams at the Kings County Medical Center, Brooklyn Eye and Ear Hospital, Massachusetts Eye and Ear Infirmary, Harvard University, and the Schepens Institute in Boston. Later in his career, he became founder and president of the Cornea Society, president of the Contact Lens Association of Ophthalmology, director of the Eye Bank Association of America, and consultant to the Food and Drug Administration and Tissue Banks International.

“Looking back over history, the greatest scientists—from people like Galileo to DaVinci to Isaac Newton—were all devoted to the advancement of their fields as well as to art, music, and the humanities overall,” says Aquavella. “The humanities provide a foundation to better understand the human experience, along with the richness and beauty of it.”

An Accomplished Career Aquavella was the first fellowship-trained corneal surgeon in the U.S. when he established his practice in Rochester in the mid-1960s, specializing in cornea and external eye disease. Having been recruited by the then-chair of the Ophthalmology Department, John Gipner, MD, Aquavella joined the University in 1962. He has been affiliated with its Flaum Eye Institute for many years and continues to treat patients there.

“Dr. Aquavella has dedicated his life to his patients and to improving their health and quality of life,” says Mark Taubman, MD, dean and CEO, University of Rochester Medical Center. “He’s an exemplary clinician, teacher, scholar, and human being who is committed to making this institution and our community a better place. We both share these convictions, along with our deep appreciation for the arts and opera.”

A Strong Partnership James and Kay Aquavella were married for 40 years, until her death in 2012. They traveled the world together, often while he participated in conferences and gave lectures. They also nurtured their shared interest in the arts and frequented places such as the Frick Museum, the Metropolitan Museum of Art, and the Metropolitan Opera in New York City; and the Corcoran Gallery of Art in Washington, D.C.

“Kay was a kind, dedicated woman,” says Aquavella. “She always felt strongly about my commitment to teaching and research and was in favor of supporting the University, both at the Medical Center and at the Memorial Art Gallery, which she very much enjoyed. She was also the driving force in our collaboration to create the first ambulatory surgical center in New York State. The ambulatory procedure is now used for 70 percent of all surgery performed in the United States.”

A Legacy of Giving

In addition to his gifts to the Memorial Art Gallery, Aquavella, established, in 2013, two endowed professorships at the University’s School of Medicine and Dentistry: the Catherine E. Aquavella Distinguished Professorship in Ophthalmology, in honor of his wife, and the James V. Aquavella, M.D., Professorship in Ophthalmology. These gifts ensure that excellence in ophthalmological research, teaching, and scholarship at the University will continue in perpetuity.

Read the full story at uofr.us/Aquavella

Why I Give: Stephen Plume (MD ’69, Res ’75)

This retired cardiothoracic surgeon and academic medical leader established an endowed scholarship to benefit future generations of medical students.

Stephen Plume (MD ’69, Res ’75)

Emeritus Professor of Surgery, Community and Family Medicine, and The Dartmouth Institute for Health Policy and Clinical Practice at the Geisel School of Medicine at Dartmouth College—has spent his career working in academic medical centers as a cardiothoracic surgeon, a faculty member, and an administrative leader. Plume recently established an endowed scholarship at the University of Rochester’s School of Medicine and Dentistry (SMD): the Stephen K. Plume, III ’69M (MD), ’75M (Res) Scholarship.”

“I’m very appreciative of what I learned at Rochester,” says Plume, who has spent most of his life in Vermont, just across the state line from Hanover, N.H. “The school and faculty members such as Dr. George Engel, who founded the biopsychosocial approach with Dr. John Romano, provided me with practical knowledge and insight that informed my entire career.”

Plume had a particular affinity for Engel, who was his professor and mentor. “This scholarship pays homage to what he meant to me,” he adds. “It’s a way for me to honor his influence and, at the same time, to support future generations of medical students.”

To make an immediate impact, Plume also established a current-use fund to have resources available to name a scholarship recipient for the 2021–22 academic year. Olanrewaju Akande, a first-year medical student, is the first Plume scholar. Recently, the two had the opportunity to meet over Zoom. “Olanrewaju is a motivated young man with a great future ahead of him,” he says. “He is deserving of a scholarship, and I am glad to support him.”

“Without Dr. Plume’s support, I truly do not envision myself sitting alongside my peers at the University of Rochester today,” says Akande. “Because of his generosity, I am here, at the School of Medicine and Dentistry—my top choice for medical school.”

What do you wish for Olanrewaju and future Plume scholars?

My wish for all medical students is to find honorable and satisfying careers in medicine. In addition to the benefits of the rigorous academic program at SMD, I’m hopeful Olanrewaju and future beneficiaries of this scholarship become exposed to and take advantage of the hallmarks of a Rochester education.

How do you think the biopsychosocial model transformed clinical care?

For me, it comes down to this: illness is an individual experience that manifests differently in each one of us. It’s personal. We can learn about named diseases in textbooks, but we do not understand an illness until we connect with the person, in the context of that person’s life, goals, and distinct environment. This approach has carried over to other aspects of my life, influencing how I interact with colleagues, institutional leaders, family, and friends.

Advice for prospective medical students?

Here, Plume elaborates on his time at the medical school and his reasons for giving back.

What was the catalyst for establishing this scholarship?

Although I’ve always supported the Medical School through its annual fund, I came away from my 50th reunion a few years ago with a wish to do something more for the institution. I reconnected with friends I hadn’t seen in decades, and I walked through spaces that held significant meaning for me. All of this rekindled feelings of loyalty and affection and prompted me to reflect on how important that time was in my life and career.

I do a lot of admissions interviewing for Geisel School of Medicine at Dartmouth. I advise prospective students not to over-intellectualize their decision. I encourage them to learn what they can about the schools they are considering, and then to ask themselves, “Will I like and trust the people I’ve met?” I remind them that the people shaping their values, whether explicitly or through what has been called “the hidden curriculum” of medical school, are at least as important as the subjects studied. Getting my medical education among those I trust and respect was one of the best decisions of my life.

Do you have counsel for those who may be considering a gift to the school?

I encourage other alumni to reflect on what their medical school experience has meant to them over the course of their careers. Then, if they are thinking about making a gift, do what feels right to help nurture the traditional values and expertise that are synonymous with the school.

Read the full story

Lucy Rorke-Adams, MD: Trailblazer, Pediatric Neuropathologist, Would-Be Opera Singer

The Flaum Eye Institute is the recipient of a generous bequest from Lucy Rorke-Adams, MD, a longtime supporter of Alex Levin, MD, chief of pediatric ophthalmology at the Institute.

As a young girl and a child of Armenian immigrants, Rorke-Adams thought that someday she’d become an opera singer. But when she was a teenager, a missed audition with a Metropolitan Opera singer set her on a different course, leading her instead to an illustrious 58-year medical career as a pediatric neuropathologist.

Her career highlights include becoming the first woman president of the medical staff at Philadelphia General Hospital and later at Children’s Hospital of Philadelphia, where she spent most of her career. She was also chair of the Department of Pathology at both institutions and acting CEO of Children’s for 18 months. She held long associations with the Philadelphia Medical Examiner’s Office, the Wistar Institute, and Wyeth Research Laboratories. She was also a professor of pathology, neurology, and pediatrics at the University of Pennsylvania’s Perelman School of Medicine.

Later in life, Rorke-Adams even became one of the trusted keepers of Albert Einstein’s brain. Here, she provides insight into her life and career.

Career Catalysts

Starting at about age 4, I loved to collect earthworms, especially after a good rain. I’d take them apart to see what I could find. I think that was the beginning of my career as a pathologist. Then, when I was a teenager—right around the time of the canceled audition—I read The Magnificent Obsession by Lloyd Douglass. It’s the story of a feckless playboy who inadvertently causes the death of a famous neurosurgeon. He tries to make amends by studying medicine. I was inspired by the man’s drive to right his wrongs and to become a neurosurgeon.

Proudest Moment

Although I have many, here’s one: In my 1981 Presidential Address to the American Association of Neuropathologists, I challenged a world authority on his long-held theory about embryonal pediatric brain tumors. That gentleman was not pleased. But by challenging him, other colleagues realized that this was fertile ground for study. In consequence, there have been many advances in our understanding of this group of childhood tumors.

A Beautiful Brain

In 1955, Dr. Thomas Harvey, the pathologist at Princeton Hospital, performed an autopsy on Albert Einstein. Five sets of microscopic slides were then made at the pathology laboratory of Dr. William Ehrich at the University of Pennsylvania. Dr. Harvey and I were students of Dr. Ehrich, though he preceded me by some years. Dr. Harvey gave one set of slides to Dr. Ehrich and some years after his death, they were given to me. Dr. Einstein died when he was 76 years old, but his brain was that of a young person. After guarding them for many years, I decided that they belonged in a museum and gifted them to the Mutter Museum of The College of Physicians of Philadelphia, where they are on display.

Reasons to Give

My parents instilled in me the importance of making my life count for something by sharing whatever talents I possessed with society at large. I tried to do that by focusing on advancing science in the hope of improving the lives of children. My late husband, C. Harry Knowles, was a brilliant scientist and physicist who held more than 400 patents and succeeded exceptionally in the company that he established. He shared a desire to invest in the next generation and chose to do this by establishing the Knowles Teacher Initiative. This initiative supports teachers by advancing their skills in teaching math and science to high school youths.

A Shared Commitment

Harry and I developed a deep friendship with Dr. Alex Levin and his wife, Faith. When we first learned of his pioneering work identifying and treating genetically induced diseases of the eyes, we decided to support him. At that time Dr. Levin was working at Wills Eye Hospital in Philadelphia. When he became chief of pediatric ophthalmology at the University of Rochester Medical Center’s Flaum Eye Institute, we redirected our support. My husband was a modest man with a profound altruistic outlook who pledged to continue supporting Dr. Levin’s important work. It now gives me great pleasure to carry out his wishes by formalizing a bequest at Flaum that will do just that.

Read the full story at uofr.us/Rorke-Adams

Use the online directory at www.alumniconnections.com/URMC to find contact information for fellow alumni.

Submit class notes to your class agent or to RochesterMedicineMagazine@urmc. rochester.edu

Note: MD alumni are listed alphabetically by class. Resident and fellow alumni follow in alphabetical order, and graduate alumni are listed separately in alphabetical order.

MD Alumni

1957

C. McCollister Evarts (Res ‘59, Res ‘64) , was honored as an American Osteopathic Association Pillar of the orthopaedic profession.

1966

Hock H. Yeoh retired in 2020 from the Southern California Kaiser Permanente Medical Group, where he served for 45 years. He practiced as a nephrologist and in several other capacities in the organization and was also on the faculty at the UCLA David Geffen School and an attending physician at West L.A. Veterans Administration Hospital and the Kaiser Permanente Medical Center. Currently, he is volunteering with the National Kidney Foundation of Southern California and is a member of the Advisory Council.

1968

Stuart Bauer received the 2021 John W, Duckett, MD, Research Excellence Award from the Urology Care Foundation of the American Urological Association for his contributions to pediatric urology.

1974

John A. Vanek released worldwide the latest book, Bedeviled, in his Father Jake Austin Mystery Series.

1975

Paul V. Williams was recently elected as secretary/treasurer of the American Academy of Allergy, Asthma, and Immunology, a position that will ascend to the presidency in 2024–25.

1976

Timothy E. Quill (Res ’79) published a new book titled Voluntarily Stopping Eating and Drinking: A Compassionate, WidelyAvailable Option for Hastening Death.

(See story on page 40.)

1985

Daniel James Briceland (Res ’86) will serve as the 2023 president of the American Academy of Ophthalmology. For more than 25 years, Briceland has worked at both the state and federal levels to protect patients’ right to safe and appropriate eye care. He was elected to leadership by the Academy’s community of 32,000 ophthalmologists.

1990

Bruce Churchill was honored in May 2021 with the inaugural Harvard University Hammonds Award for Exceptional Service to the LGBTQ Community.

Thomas A. Sweeney served as vice-chair of the Department of Emergency Medicine at Christiana Care Health Services in Newark, Del., for 18 years. He is president of the doctors for emergency services, staffing Christiana Care emergency departments and the residency programs with 100 attending emergency physicians and physician assistants.

1992

Charles J. Geilfuss III is retiring from the practice of pathology after 27 years at Trident Health System.

1996

Joshua Goldstein was recently named senior associate dean for graduate medical education and promoted to professor of pediatrics, medical education, and neurology at Northwestern University Feinberg School of Medicine.

1997

Mark E. Basham is co-author of the recently published book Thriving in Academia: Building a Career at a Teaching-Focused Institution. This book provides advice for graduate students and current faculty seeking to build thriving careers at teaching-focused institutions. In the book, he explains how to develop core teaching competencies; choose advising philosophies for mentoring individual students, groups, and clubs; perform high-quality faculty service; and achieve scholarly, creative, and research goals—all while managing a high teaching load.

Natalie Ann Bello has been named director of hypertension research in the Smidt Heart Institute’s Department of Cardiology at Cedars-Sinai in Los Angeles. She was previously director of research at the Women’s Heart Center and assistant professor of Medicine at Columbia University Medical Center. In 2018, Bello designed a smartphone app called Love My Heart to educate women about heart disease risk factors and lifestyle interventions. She was selected by Cardiology Today as a Next Gen Innovator in 2018, and by the American College of Cardiology to participate in Clinical Trials Research: Upping Your Game in 2020

David B. Nash (MD ’81), MBA, who has devoted his career to improving health care quality and patient safety, is co-author of How Covid Crashed the System: A Guide to Fixing American Health Care, scheduled for release in October.

“The pandemic inspired me to further articulate my thoughts in a comprehensive way,” says Nash, who wrote the book alongside author Charles Wohlforth. The authors “pick up the pieces of the Covid disaster like investigators of a crashed airliner, finding the root causes of America’s failure to cope, and delivering surprising answers that may reorient how you think about your own health,” according to publisher Rowman & Littlefield.

Nash is founding dean emeritus and the Dr. Raymond C. & Doris N. Grandon Professor of Health Policy at Jefferson College of Population Health at Thomas Jefferson University in Philadelphia. He returned to the School of Medicine and Dentistry in May 2018 to deliver the commencement address.

Most recently, Nash created a fund to support the Nash Family Summer Research Scholar. Each summer, the fund will support a University of Rochester School of Medicine and Dentistry medical student’s pursuit of patient safety and quality improvement through independent study.

How Covid Crashed the System is available for pre-order at rowman.com

SMD Alum Puts Medical Skills, Ukrainian Roots, to Use at Polish Border

Standing by wasn’t an option for Alexander Hajduczok (MD ’18) , who spent nearly two weeks at the Ukraine-Poland border at the end of March. His Ukrainian heritage wouldn’t allow him to just watch news coverage as more than four million refugees poured across the border seeking safety.

Hajduczok, whose grandparents fled Ukraine after World War II, said his reasons for being there as a medical aide were both personal and professional.

“Watching the news, I kept thinking, ‘I want to help, where can I donate?’” says Hajduczok, a first-year cardiology fellow at Thomas Jefferson University Hospital in Philadelphia. “It wasn’t clear to me how I could help until I connected through people in (my) cardiology network and others on social media.”

A colleague who was also helping at the border suggested he come. Hajduczok paused briefly to figure out how he’d get the time off from his fellowship.

“It was a flood of emotions,” he says. “I just kept coming back to the fact that I couldn’t sit on the sidelines. I emailed the chair of the department and got support from my fellows. I was flying out within three or four days.”

For 10 days, Hajduczok was stationed in a refugee camp’s field medical tent inside the Polish border in a small town called Medyka, where he and others provided medical aid while frequently crossing the border into Ukraine to drop off supplies and to discuss medical concerns with Ukrainian doctors.

“We assembled what we had or had our contacts from home sending supplies and helping facilitate things from afar,” he says. “It was pretty powerful to know that we were helping make a difference in many ways.”

Hajduczok grew up speaking, reading, and writing Ukrainian. His family, including both sets of grandparents, made sure he understood the language and the history of his people. His grandparents were war refugees, driven from their homes when the Soviets crossed Ukraine.

“They were in forced labor camps and were taken to displaced person camps; that’s how one set of my grandparents met,” he says. “Being in Poland at the Ukraine border… my childhood, my upbringing all came back to me there; I grew up speaking 1940s Ukrainian, but I was able to understand mostly everything in general context. It gave me the feeling that I was meant to be there at this time.”

Raised in Buffalo, Hajduczok has Rochester roots. His paternal family lived in Webster, and he spent time between both Western New York cities.

Knowing the languages spoken at the border—Russian, Ukrainian, and Polish— certainly helped Hajduczok. However, translations were, at times, muddled or hard to understand. Though he grew up speaking Ukrainian, he hadn’t learned the medical side of communication.

“There was a language barrier, which made it a whirlwind of confusion at times,” he says. “But providing basic medical care to anyone, no matter what language they spoke or what ethnic background they had, came with relative ease.”

Working out of medical field tents, he and others treated people suffering everything from exhaustion, stress, dehydration, and seizures, to more severe cases such as bomb-blast injuries and gunshot wounds resulting in fractured ribs.

We will stay strong and build up the resilience of the Ukraine -Alexander Hajduczok

In a time of struggle and adversity, he saw people teaming up to help their fellow humans.

“It was inspiring to see people working as one,” he says. “There were so many people pulling together. Everyone helping carry themselves and each other. It’s leveling to see. It kept things stable for those who need security during this time of strife.

Featured on ABC’s World News Tonight in March, Hajduczok recalled being quite emotional during his interview.

“I was choked up; they asked a question and, suddenly, I was filled with emotions,” he says. “It was like waterworks—genuine and from the heart. I wish it wasn’t like that but it sure painted a picture of what it’s like there.”

Back at home, his family was also going through all of the emotions. Hajduczok said his parents were proud, scared, and nervous. He was stationed close to Przemys ’ l, a small but developed town (think shopping plazas, houses, schools, etc.). It was unnerving at times to know that people were forced to leave all they had, all they knew, all they had built for themselves, uncertain of ever returning home.

“Yet, despite their great losses, there wasn’t a lot of complaining,” he says. “It was their reality; they are going to start a new life for the time being, many with the hope that they will someday be able to return to their homes and loved ones.”

Coming “home” to Rochester means something else to Hajduczok. He owns a property near URMC that he rents to medical students and visits the area when he can. In addition to his medical degree, his 11 years in Rochester included earning bachelor’s degrees in biochemistry and economics, membership in Delta Upsilon fraternity, and playing hockey with University staff and friends. It was during his time in med school that Hajduczok began to focus on cardiology.

“I fell in love with cardiology and knew this was what I wanted to pursue,” he says. He matched at Penn State University at Hershey for residency, which led him to Philadelphia for his fellowship.

Match Day brought a big opportunity to Hajduczok. He was accepted at Penn State University at Hershey and ultimately landed in Philadelphia, where he is in his first year of cardiology fellowship. He’ll have two more years in this capacity and is looking forward to his future as a cardiologist.

While his future is still being determined, Hajduczok continues to keep strong ties to the Rochester area, where his Ukrainian roots took hold. He grew up doing Ukrainian dancing in the Rochester and Buffalo areas and also attended Ukrainian summer camps in Letchworth State Park.

“When I was a kid at camp, we spent long summer weeks in Army tents,” he says. “When I stayed in Poland, they utilized the exact same type of tents. Of course, I knew all of the tent tricks and functions after using them every summer as a kid. Every zipper, stake, nook, and pocket. I remember learning how to waterproof them, and also how to keep the wood-burning stove going. The trick is to never let the fire go out.”

It’s that passion to keep the fire lit that motivates Hajduczok in every aspect of his life.

“We will stay strong and build up the resilience of the Ukraine,” he proudly says.

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